A Novel Paclitaxel Microemulsion Containing a Reduced Amount of Cremophor EL : Pharmacokinetics, Biodistribution, and In Vivo Antitumor Efficacy and Safety
Joint Authors
Wang, Ying
Nie, Shu-Fang
Zhao, Xin
Pan, Wei-San
Zhang, Xuan
Zhang, Qiang
Zhao, Bing-Xiang
Wang, Xin
Chen, Su
Wu, Ke-Chun
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The purpose of this study was to prepare a novel paclitaxel (PTX) microemulsion containing a reduced amount of Cremophor EL (CrEL) which had similar pharmacokinetics and antitumor efficacy as the commercially available PTX injection, but a significantly reduced allergic effect due to the CrEL.
The pharmacokinetics, biodistribution, in vivo antitumor activity and safety of PTX microemulsion was evaluated.
The results of pharmacokinetic and distribution properties of PTX in the microemulsion were similar to those of the PTX injection.
The antitumor efficacy of the PTX microemulsion in OVCRA-3 and A 549 tumor-bearing animals was similar to that of PTX injection.
The PTX microemulsion did not cause haemolysis, erythrocyte agglutination or simulative reaction.
The incidence and degree of allergic reactions exhibited by the PTX microemulsion group, with or without premedication, were significantly lower than those in the PTX injection group (P<.01).
In conclusion, the PTX microemulsion had similar pharmacokinetics and anti-tumor efficacy to the PTX injection, but a significantly reduced allergic effect due to CrEL, indicating that the PTX microemulsion overcomes the disadvantages of the conventional PTX injection and is one way of avoiding the limitations of current injection product while providing suitable therapeutic efficacy.
American Psychological Association (APA)
Wang, Ying& Wu, Ke-Chun& Zhao, Bing-Xiang& Zhao, Xin& Wang, Xin& Chen, Su…[et al.]. 2011. A Novel Paclitaxel Microemulsion Containing a Reduced Amount of Cremophor EL : Pharmacokinetics, Biodistribution, and In Vivo Antitumor Efficacy and Safety. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-503669
Modern Language Association (MLA)
Wang, Ying…[et al.]. A Novel Paclitaxel Microemulsion Containing a Reduced Amount of Cremophor EL : Pharmacokinetics, Biodistribution, and In Vivo Antitumor Efficacy and Safety. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-503669
American Medical Association (AMA)
Wang, Ying& Wu, Ke-Chun& Zhao, Bing-Xiang& Zhao, Xin& Wang, Xin& Chen, Su…[et al.]. A Novel Paclitaxel Microemulsion Containing a Reduced Amount of Cremophor EL : Pharmacokinetics, Biodistribution, and In Vivo Antitumor Efficacy and Safety. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-503669
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503669