The Lipid Moiety of Haemozoin (Malaria Pigment) and P. falciparum Parasitised Red Blood Cells Bind Synthetic and Native Endothelin-1
Joint Authors
Omodeo-Salè, Fausta
Olliaro, Piero
Basilico, Nicoletta
Taramelli, Donatella
Sisto, Francesca
Parapini, Silvia
Ravagnani, Fernando
Coghi, Paolo
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Endothelin1 (ET-1) is a 21-amino acid peptide produced by the vascular endothelium under hypoxia, that acts locally as regulator of vascular tone and inflammation.
The role of ET-1 in Plasmodium falciparum malaria is unknown, although tissue hypoxia is frequent as a result of the cytoadherence of parasitized red blood cell (pRBC) to the microvasculature.
Here, we show that both synthetic and endothelial-derived ET-1 are removed by parasitized RBC (D10 and W2 strains, chloroquine sensitive, and resistant, resp.) and native haemozoin (HZ, malaria pigment), but not by normal RBC, delipidized HZ, or synthetic beta-haematin (BH).
The effect is dose dependent, selective for ET-1, but not for its precursor, big ET-1, and not due to the proteolysis of ET-1.
The results indicate that ET-1 binds to the lipids moiety of HZ and membranes of infected RBCs.
These findings may help understanding the consequences of parasite sequestration in severe malaria.
American Psychological Association (APA)
Basilico, Nicoletta& Parapini, Silvia& Sisto, Francesca& Omodeo-Salè, Fausta& Coghi, Paolo& Ravagnani, Fernando…[et al.]. 2010. The Lipid Moiety of Haemozoin (Malaria Pigment) and P. falciparum Parasitised Red Blood Cells Bind Synthetic and Native Endothelin-1. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-503675
Modern Language Association (MLA)
Basilico, Nicoletta…[et al.]. The Lipid Moiety of Haemozoin (Malaria Pigment) and P. falciparum Parasitised Red Blood Cells Bind Synthetic and Native Endothelin-1. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-503675
American Medical Association (AMA)
Basilico, Nicoletta& Parapini, Silvia& Sisto, Francesca& Omodeo-Salè, Fausta& Coghi, Paolo& Ravagnani, Fernando…[et al.]. The Lipid Moiety of Haemozoin (Malaria Pigment) and P. falciparum Parasitised Red Blood Cells Bind Synthetic and Native Endothelin-1. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-503675
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503675