Applications of Propargyl Esters of Amino Acids in Solution-Phase Peptide Synthesis
Joint Authors
Megha, Rajendran
Ramapanicker, Ramesh
Chandrasekaran, Srinivasan
Gupta, Rohit
Source
International Journal of Peptides
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Propargyl esters are employed as effective protecting groups for the carboxyl group during solution-phase peptide synthesis.
The propargyl ester groups can be introduced onto free amino acids by treating them with propargyl alcohol saturated with HCl.
The reaction between propargyl groups and tetrathiomolybdate is exploited to deblock the propargyl esters.
The removal of the propargyl group with the neutral reagent tetrathiomolybdate ensures that most of the other protecting groups used in peptide synthesis are untouched.
Both acid labile and base labile protecting groups can be removed in the presence of a propargyl ester.
Amino acids protected as propargyl esters are employed to synthesize di- to tetrapeptides in solution-phase demonstrating the possible synthetic utilities of the methodology.
The methodology described here could be a valuable addition to currently available strategies for peptide synthesis.
American Psychological Association (APA)
Ramapanicker, Ramesh& Gupta, Rohit& Megha, Rajendran& Chandrasekaran, Srinivasan. 2011. Applications of Propargyl Esters of Amino Acids in Solution-Phase Peptide Synthesis. International Journal of Peptides،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-503679
Modern Language Association (MLA)
Ramapanicker, Ramesh…[et al.]. Applications of Propargyl Esters of Amino Acids in Solution-Phase Peptide Synthesis. International Journal of Peptides No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-503679
American Medical Association (AMA)
Ramapanicker, Ramesh& Gupta, Rohit& Megha, Rajendran& Chandrasekaran, Srinivasan. Applications of Propargyl Esters of Amino Acids in Solution-Phase Peptide Synthesis. International Journal of Peptides. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-503679
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503679