Therapeutic Effects of PADRE-BAFF Autovaccine on Rat Adjuvant Arthritis
Joint Authors
Zhang, Wei
Li, Wei-na
Zhang, Ying-qi
Gao, Yuan
Wang, Zeng-lu
Zhang, Cun
Li, Meng
Gao, Mei-li
Hao, Qiang
Wang, Xian-feng
Mu, Nan
Xue, Xiao-chang
Shu, Zhen
Feng, Guo-dong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
B cell activating factor (BAFF) is a cytokine of tumor necrosis factor family mainly produced by monocytes and dendritic cells.
BAFF can regulate the proliferation, differentiation, and survival of B lymphocytes by binding with BAFF-R on B cell membrane.
Accumulating evidences showed that BAFF played crucial roles and was overexpressed in various autoimmune diseases such as systemic lupus erythematous (SLE) and rheumatoid arthritis (RA).
This suggests that BAFF may be a therapeutic target for these diseases.
In the present study, we developed a BAFF therapeutic vaccine by coupling a T helper cell epitope AKFVAAWTLKAA (PADRE) to the N terminus of BAFF extracellular domains (PADRE-BAFF) and expressed this fusion protein in Escherichia coli.
The purified vaccine can induce high titer of neutralizing BAFF antibodies and ameliorate the syndrome of complete Freund’s adjuvant (CFA) induced rheumatoid arthritis in rats.
Our data indicated that the BAFF autovaccine may be a useful candidate for the treatment of some autoimmune diseases associated with high level of BAFF.
American Psychological Association (APA)
Feng, Guo-dong& Xue, Xiao-chang& Gao, Mei-li& Wang, Xian-feng& Shu, Zhen& Mu, Nan…[et al.]. 2014. Therapeutic Effects of PADRE-BAFF Autovaccine on Rat Adjuvant Arthritis. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-503680
Modern Language Association (MLA)
Feng, Guo-dong…[et al.]. Therapeutic Effects of PADRE-BAFF Autovaccine on Rat Adjuvant Arthritis. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-503680
American Medical Association (AMA)
Feng, Guo-dong& Xue, Xiao-chang& Gao, Mei-li& Wang, Xian-feng& Shu, Zhen& Mu, Nan…[et al.]. Therapeutic Effects of PADRE-BAFF Autovaccine on Rat Adjuvant Arthritis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-503680
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503680