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The Molecular Biology of Vestibular Schwannomas and Its Association with Hearing Loss : A Review
Joint Authors
Gavilan, Javier
Rodrigues, F. Yuri
Nistal, Manuel
Rey, Juan A.
Lassaletta, Luis
Torres-Martín, Miguel
Castresana, Javier S.
Celis-Aguilar, Erika
Source
Genetics Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hearing loss is the most common symptom in patients with vestibular schwannoma (VS).
In the past, compressive mechanisms caused by the tumoral mass and its growth have been regarded as the most likely causes of the hearing loss associated with VS.
Interestingly, new evidence proposes molecular mechanisms as an explanation for such hearing loss.
Among the molecular mechanisms proposed are methylation of TP73, negative expression of cyclin D1, expression of B7-H1, increased expression of the platelet-derived growth factor A, underexpression of PEX5L, RAD54B, and PSMAL, and overexpression of CEA.
Many molecular mechanisms are involved in vestibular schwannoma development; we review some of these mechanisms with special emphasis on hearing loss associated with vestibular schwannoma.
American Psychological Association (APA)
Celis-Aguilar, Erika& Lassaletta, Luis& Torres-Martín, Miguel& Rodrigues, F. Yuri& Nistal, Manuel& Castresana, Javier S.…[et al.]. 2012. The Molecular Biology of Vestibular Schwannomas and Its Association with Hearing Loss : A Review. Genetics Research International،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-503708
Modern Language Association (MLA)
Celis-Aguilar, Erika…[et al.]. The Molecular Biology of Vestibular Schwannomas and Its Association with Hearing Loss : A Review. Genetics Research International No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-503708
American Medical Association (AMA)
Celis-Aguilar, Erika& Lassaletta, Luis& Torres-Martín, Miguel& Rodrigues, F. Yuri& Nistal, Manuel& Castresana, Javier S.…[et al.]. The Molecular Biology of Vestibular Schwannomas and Its Association with Hearing Loss : A Review. Genetics Research International. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-503708
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503708