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Repeated-Doses Toxicity Study of the Essential Oil of Hyptis martiusii Benth. (Lamiaceae) in Swiss Mice
Joint Authors
Albuquerque, Giwellington Silva
Silva-Neto, Jacinto da Costa
Freire Rocha Caldas, Germana
Wanderley, Almir Gonçalves
Costa-Silva, João Henrique
Araújo, Alice Valença
Costa, José Galberto Martins da
Leite, Ana Cristina Lima
de Menezes, Irwin Rose Alencar
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hyptis martiusii Benth.
(Lamiaceae) is found in abundance in Northeastern Brazil where it is used in traditional medicine to treat gastric disorders.
Since there are no studies reporting the toxicity and safety profile of this species, we investigated repeated-doses toxicity of the essential oil of Hyptis martiusii (EOHM).
Swiss mice of both sexes were orally treated with EOHM (100 and 500 mg/kg) for 30 days, and biochemical, hematological, and morphological parameters were determined.
No toxicity signs or deaths were recorded during the treatment with EOHM.
The body weight gain was not affected, but there was an occasional variation in water and food consumption among mice of both sexes treated with both doses.
The hematological and biochemical profiles did not show significant differences except for a decrease in the MCV and an increase in albumin, but these variations are within the limits described for the species.
The microscopic analysis showed changes in liver, kidneys, lungs, and spleen; however, these changes do not have clinical relevance since they varied among the groups, including the control group.
The results indicate that the treatment of repeated-doses with the essential oil of Hyptis martiusii showed low toxicity in mice.
American Psychological Association (APA)
Freire Rocha Caldas, Germana& Araújo, Alice Valença& Albuquerque, Giwellington Silva& Silva-Neto, Jacinto da Costa& Costa-Silva, João Henrique& de Menezes, Irwin Rose Alencar…[et al.]. 2013. Repeated-Doses Toxicity Study of the Essential Oil of Hyptis martiusii Benth. (Lamiaceae) in Swiss Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-503709
Modern Language Association (MLA)
Freire Rocha Caldas, Germana…[et al.]. Repeated-Doses Toxicity Study of the Essential Oil of Hyptis martiusii Benth. (Lamiaceae) in Swiss Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-503709
American Medical Association (AMA)
Freire Rocha Caldas, Germana& Araújo, Alice Valença& Albuquerque, Giwellington Silva& Silva-Neto, Jacinto da Costa& Costa-Silva, João Henrique& de Menezes, Irwin Rose Alencar…[et al.]. Repeated-Doses Toxicity Study of the Essential Oil of Hyptis martiusii Benth. (Lamiaceae) in Swiss Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-503709
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503709