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Pathobiologic Markers of the Ewing Sarcoma Family of Tumors : State of the Art and Prediction of Behaviour
Joint Authors
Dickman, Paul
Pinto, Alfredo
Parham, David
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-14
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Over the past three decades, the outcome of Ewing sarcoma family tumor (ESFT) patients who are nonmetastatic at presentation has improved considerably.
The prognosis of patients with metastatic disease at the time of diagnosis and recurrence after therapy remains dismal.
Drug-resistant disease at diagnosis or at relapse remains a major cause of mortality among patients diagnosed with ESFT.
In order to improve the outcome for patients with potential relapse, there is an urgent need to find reliable markers that either predict tumor behaviour at diagnosis or identify therapeutic molecular targets at the time of recurrence.
An improved understanding of the cell of origin and the molecular pathways that regulate tumorigenicity in ESFT should aid us in the search for novel therapies for ESFT.
The purpose of this paper is thus to outline current concepts of sarcomagenesis in ESFT and to discuss ESFT patterns of differentiation and molecular markers that might affect prognosis or direct future therapeutic development.
American Psychological Association (APA)
Pinto, Alfredo& Dickman, Paul& Parham, David. 2010. Pathobiologic Markers of the Ewing Sarcoma Family of Tumors : State of the Art and Prediction of Behaviour. Sarcoma،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-503713
Modern Language Association (MLA)
Pinto, Alfredo…[et al.]. Pathobiologic Markers of the Ewing Sarcoma Family of Tumors : State of the Art and Prediction of Behaviour. Sarcoma No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-503713
American Medical Association (AMA)
Pinto, Alfredo& Dickman, Paul& Parham, David. Pathobiologic Markers of the Ewing Sarcoma Family of Tumors : State of the Art and Prediction of Behaviour. Sarcoma. 2010. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-503713
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503713