Focal Point Theory Models for Dissecting Dynamic Duality Problems of Microbial Infections
Joint Authors
Huang, Sheng-He
Zhou, Wensheng
Jong, Ambrose
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-03-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Extending along the dynamic continuum from conflict to cooperation, microbial infections always involve symbiosis (Sym) and pathogenesis (Pat).
There exists a dynamic Sym-Pat duality (DSPD) in microbial infection that is the most fundamental problem in infectomics.
DSPD is encoded by the genomes of both the microbes and their hosts.
Three focal point (FP) theory-based game models (pure cooperative, dilemma, and pure conflict) are proposed for resolving those problems.
Our health is associated with the dynamic interactions of three microbial communities (nonpathogenic microbiota (NP) (Cooperation), conditional pathogens (CP) (Dilemma), and unconditional pathogens (UP) (Conflict)) with the hosts at different health statuses.
Sym and Pat can be quantitated by measuring symbiotic index (SI), which is quantitative fitness for the symbiotic partnership, and pathogenic index (PI), which is quantitative damage to the symbiotic partnership, respectively.
Symbiotic point (SP), which bears analogy to FP, is a function of SI and PI.
SP-converting and specific pathogen-targeting strategies can be used for the rational control of microbial infections.
American Psychological Association (APA)
Huang, Sheng-He& Zhou, Wensheng& Jong, Ambrose. 2008. Focal Point Theory Models for Dissecting Dynamic Duality Problems of Microbial Infections. Journal of Biomedicine and Biotechnology،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-503722
Modern Language Association (MLA)
Huang, Sheng-He…[et al.]. Focal Point Theory Models for Dissecting Dynamic Duality Problems of Microbial Infections. Journal of Biomedicine and Biotechnology No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-503722
American Medical Association (AMA)
Huang, Sheng-He& Zhou, Wensheng& Jong, Ambrose. Focal Point Theory Models for Dissecting Dynamic Duality Problems of Microbial Infections. Journal of Biomedicine and Biotechnology. 2008. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-503722
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503722