The Effect of Glycyrrhetinic Acid on Pharmacokinetics of Cortisone and Its Metabolite Cortisol in Rats
Joint Authors
Li, Wan-Shu
Wang, Shuang-Hu
Wang, Zhe
Ge, Ren-Shan
Chen, Lian-Guo
Sun, Wei
Lin, Dan
Chen, Xiao-Le
Hu, Guo-Xin
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The purpose of this paper is to study pharmacokinetics of cortisone (E) and its metabolite cortisol (F) in rats after administration of glycyrrhetinic acid (GA) and cortisone.
Healthy male SD rats were randomized to be given 20 mg/kg E or E combined with 10 mg/kg GA.
Blood samples were collected at 5, 10, 20, 40, 60, 90, 120, 150, 180, and 240 min after administration.
The serum concentrations of E and F were determined by HLPC and pharmacokinetic parameters were calculated using DASver2.0 software.
The parameters of AUC(0−t), AUC(0−∞), and Cmax for E in the group of E + GA were significantly higher than those in the group of E (P<0.01); the half-time (t1/2β) was extended compared to E (P<0.05) and CL/F was dropped obviously (P<0.01).
The rise in AUC(0−t), AUC(0−∞), and Cmax for cortisol in the group of E + GA was significantly compared to the group of E (P<0.01).
CL/F was lower than E (P<0.01) and the half-time (t1/2β) was slightly extended.
In this study, we find that GA restrains the metabolism of E and F and thus increases AUC, t1/2β, and Cmax of E and F, which may be related to its inhibition effect on 11β-hydroxysteroid dehydrogenase (11β-HSD).
American Psychological Association (APA)
Lin, Dan& Sun, Wei& Wang, Zhe& Chen, Lian-Guo& Chen, Xiao-Le& Wang, Shuang-Hu…[et al.]. 2012. The Effect of Glycyrrhetinic Acid on Pharmacokinetics of Cortisone and Its Metabolite Cortisol in Rats. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-503723
Modern Language Association (MLA)
Lin, Dan…[et al.]. The Effect of Glycyrrhetinic Acid on Pharmacokinetics of Cortisone and Its Metabolite Cortisol in Rats. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-503723
American Medical Association (AMA)
Lin, Dan& Sun, Wei& Wang, Zhe& Chen, Lian-Guo& Chen, Xiao-Le& Wang, Shuang-Hu…[et al.]. The Effect of Glycyrrhetinic Acid on Pharmacokinetics of Cortisone and Its Metabolite Cortisol in Rats. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-503723
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503723