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Dependence of Acute Myeloid Leukemia on Adhesion within the Bone Marrow Microenvironment
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-04
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Acute myeloid leukemia (AML) cells home to the endosteal region of the bone marrow.
They interact with bone marrow stromal components including extracellular matrix proteins, glycosaminoglycans, and stromal cells, by which they derive proliferative and growth inhibitory signals.
Furthermore, adhesion to marrow stroma confers chemotherapy drug resistance and thereby promotes leukemia survival.
A subpopulation of the leukemic blasts, known as leukemia stem cells, that are capable of propagating the leukemia, remain sheltered in the bone marrow microenvironment, exhibit resistance to chemotherapy, and serve as the origin of relapse after a variable period of remission.
Detachment of these cells from the bone marrow in combination with chemotherapy may improve the outcome of therapy for AML.
American Psychological Association (APA)
Becker, Pamela S.. 2012. Dependence of Acute Myeloid Leukemia on Adhesion within the Bone Marrow Microenvironment. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-503734
Modern Language Association (MLA)
Becker, Pamela S.. Dependence of Acute Myeloid Leukemia on Adhesion within the Bone Marrow Microenvironment. The Scientific World Journal No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-503734
American Medical Association (AMA)
Becker, Pamela S.. Dependence of Acute Myeloid Leukemia on Adhesion within the Bone Marrow Microenvironment. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-503734
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503734