Incidence of Severe Hepatotoxicity Related to Antiretroviral Therapy in HIVHCV Coinfected Patients

Abstract EN

Introduction.

Hepatotoxicity is a concern in HIV/hepatitis C virus (HCV) coinfected patients due to their underlying liver disease.

This study assessed the incidence of hepatotoxicity in HIV/HCV co-infected patients in two outpatient infectious diseases clinics.

Methods.

HIV/HCV co-infected adults were included in this retrospective study if they were PI or NNRTI naïve at their first clinic visit and were initiated on an NNRTI- and/or PI-based antiretroviral regimen.

Patients were excluded if they had active or chronic hepatitis B virus (HBV).

The primary objective was to determine the overall incidence of severe hepatotoxicity.

Results.

Fifty-six of the 544 patients identified met inclusion criteria.

The incidence of severe hepatotoxicity was 10.7% (6/56 patients).

Severe hepatotoxicity occurred with efavirenz (N=2), nevirapine (N=1), indinavir (N=1), nelfinavir (N=1), and saquinavir/ritonavir (N=1).

Conclusion.

The incidence of severe hepatotoxicity appears to be low in this retrospective analysis of HIV/HCV co-infected patients receiving a PI-and/or NNRTI-based regimen.