Incidence of Severe Hepatotoxicity Related to Antiretroviral Therapy in HIVHCV Coinfected Patients
Joint Authors
Shipp, Kenneth
Clarke, Amy
Heil, Emily L.
Johnson, Melissa D.
Townsend, Mary L.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-26
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Introduction.
Hepatotoxicity is a concern in HIV/hepatitis C virus (HCV) coinfected patients due to their underlying liver disease.
This study assessed the incidence of hepatotoxicity in HIV/HCV co-infected patients in two outpatient infectious diseases clinics.
Methods.
HIV/HCV co-infected adults were included in this retrospective study if they were PI or NNRTI naïve at their first clinic visit and were initiated on an NNRTI- and/or PI-based antiretroviral regimen.
Patients were excluded if they had active or chronic hepatitis B virus (HBV).
The primary objective was to determine the overall incidence of severe hepatotoxicity.
Results.
Fifty-six of the 544 patients identified met inclusion criteria.
The incidence of severe hepatotoxicity was 10.7% (6/56 patients).
Severe hepatotoxicity occurred with efavirenz (N=2), nevirapine (N=1), indinavir (N=1), nelfinavir (N=1), and saquinavir/ritonavir (N=1).
Conclusion.
The incidence of severe hepatotoxicity appears to be low in this retrospective analysis of HIV/HCV co-infected patients receiving a PI-and/or NNRTI-based regimen.
American Psychological Association (APA)
Heil, Emily L.& Townsend, Mary L.& Shipp, Kenneth& Clarke, Amy& Johnson, Melissa D.. 2010. Incidence of Severe Hepatotoxicity Related to Antiretroviral Therapy in HIVHCV Coinfected Patients. AIDS Research and Treatment،Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-503740
Modern Language Association (MLA)
Heil, Emily L.…[et al.]. Incidence of Severe Hepatotoxicity Related to Antiretroviral Therapy in HIVHCV Coinfected Patients. AIDS Research and Treatment No. 2010 (2010), pp.1-4.
https://search.emarefa.net/detail/BIM-503740
American Medical Association (AMA)
Heil, Emily L.& Townsend, Mary L.& Shipp, Kenneth& Clarke, Amy& Johnson, Melissa D.. Incidence of Severe Hepatotoxicity Related to Antiretroviral Therapy in HIVHCV Coinfected Patients. AIDS Research and Treatment. 2010. Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-503740
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503740