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Evolving Trends in the Hepatitis C Virus Molecular Epidemiology Studies : From the Viral Sequences to the Human Genome
Joint Authors
Gadano, Adrián
Argibay, Pablo
Trinks, Julieta
Source
Epidemiology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hepatitis C virus (HCV) represents a major worldwide public health problem.
The search for the key molecular biomarkers that may provide insight on the basis of the differences in disease progression, severity, and response to therapy is crucial for understanding the natural history of HCV, for estimating the burden of infection and for developing preventive interventions.
Initially, molecular epidemiology studies have focused on studying the viral genetic diversity (genotypes, genetic variants, specific nucleotide and amino acid substitutions).
However, the clinical heterogeneities of HCV infection and the imperfect predictability of the response to treatment have suggested the need to search for host genetic biomarkers.
This led to the discovery of genetic polymorphisms playing a major role in the evolution of infection, as well as in treatment response and adverse effects, such as IL-28B, ITPA, and IP-10.
As a consequence, nowadays the focus of molecular epidemiology studies has turned from the viral to the human genome.
This paper will cover recent reports on the subject describing the most relevant viral as well as host genetic risk factors analyzed by past and current HCV molecular epidemiology studies.
American Psychological Association (APA)
Trinks, Julieta& Gadano, Adrián& Argibay, Pablo. 2012. Evolving Trends in the Hepatitis C Virus Molecular Epidemiology Studies : From the Viral Sequences to the Human Genome. Epidemiology Research International،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-503756
Modern Language Association (MLA)
Trinks, Julieta…[et al.]. Evolving Trends in the Hepatitis C Virus Molecular Epidemiology Studies : From the Viral Sequences to the Human Genome. Epidemiology Research International No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-503756
American Medical Association (AMA)
Trinks, Julieta& Gadano, Adrián& Argibay, Pablo. Evolving Trends in the Hepatitis C Virus Molecular Epidemiology Studies : From the Viral Sequences to the Human Genome. Epidemiology Research International. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-503756
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503756