Lung Oxidative Damage by Hypoxia

Joint Authors

Tuesta, M.
Araneda, O. F.

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-18, 18 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-08-26

Country of Publication

Egypt

No. of Pages

18

Main Subjects

Natural & Life Sciences (Multidisciplinary)
Biology

Abstract EN

One of the most important functions of lungs is to maintain an adequate oxygenation in the organism.

This organ can be affected by hypoxia facing both physiological and pathological situations.

Exposure to this condition favors the increase of reactive oxygen species from mitochondria, as from NADPH oxidase, xanthine oxidase/reductase, and nitric oxide synthase enzymes, as well as establishing an inflammatory process.

In lungs, hypoxia also modifies the levels of antioxidant substances causing pulmonary oxidative damage.

Imbalance of redox state in lungs induced by hypoxia has been suggested as a participant in the changes observed in lung function in the hypoxic context, such as hypoxic vasoconstriction and pulmonary edema, in addition to vascular remodeling and chronic pulmonary hypertension.

In this work, experimental evidence that shows the implied mechanisms in pulmonary redox state by hypoxia is reviewed.

Herein, studies of cultures of different lung cells and complete isolated lung and tests conducted in vivo in the different forms of hypoxia, conducted in both animal models and humans, are described.

American Psychological Association (APA)

Araneda, O. F.& Tuesta, M.. 2012. Lung Oxidative Damage by Hypoxia. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-503770

Modern Language Association (MLA)

Araneda, O. F.& Tuesta, M.. Lung Oxidative Damage by Hypoxia. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-503770

American Medical Association (AMA)

Araneda, O. F.& Tuesta, M.. Lung Oxidative Damage by Hypoxia. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-503770

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-503770