Lung Oxidative Damage by Hypoxia
Joint Authors
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-26
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
One of the most important functions of lungs is to maintain an adequate oxygenation in the organism.
This organ can be affected by hypoxia facing both physiological and pathological situations.
Exposure to this condition favors the increase of reactive oxygen species from mitochondria, as from NADPH oxidase, xanthine oxidase/reductase, and nitric oxide synthase enzymes, as well as establishing an inflammatory process.
In lungs, hypoxia also modifies the levels of antioxidant substances causing pulmonary oxidative damage.
Imbalance of redox state in lungs induced by hypoxia has been suggested as a participant in the changes observed in lung function in the hypoxic context, such as hypoxic vasoconstriction and pulmonary edema, in addition to vascular remodeling and chronic pulmonary hypertension.
In this work, experimental evidence that shows the implied mechanisms in pulmonary redox state by hypoxia is reviewed.
Herein, studies of cultures of different lung cells and complete isolated lung and tests conducted in vivo in the different forms of hypoxia, conducted in both animal models and humans, are described.
American Psychological Association (APA)
Araneda, O. F.& Tuesta, M.. 2012. Lung Oxidative Damage by Hypoxia. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-503770
Modern Language Association (MLA)
Araneda, O. F.& Tuesta, M.. Lung Oxidative Damage by Hypoxia. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-503770
American Medical Association (AMA)
Araneda, O. F.& Tuesta, M.. Lung Oxidative Damage by Hypoxia. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-503770
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503770