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Manipulating Protein Acetylation in Breast Cancer : A Promising Approach in Combination with Hormonal Therapies?
Joint Authors
Balaguer, Patrick
Cavailles, Vincent
Dalenc, Florence
Boulle, Nathalie
Linares, Aurélien
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-06
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Estrogens play an essential role in the normal physiology of the breast as well as in mammary tumorigenesis.
Their effects are mediated by two nuclear estrogen receptors, ERα and β, which regulate transcription of specific genes by interacting with multiprotein complexes, including histone deacetylases (HDACs).
During the past few years, HDACs have raised great interest as therapeutic targets in the field of cancer therapy.
In breast cancer, several experimental arguments suggest that HDACs are involved at multiple levels in mammary tumorigenesis: their expression is deregulated in breast tumors; they interfere with ER signaling in intricate ways, restoring hormone sensitivity in models of estrogen resistance, and they clinically represent new potential targets for HDACs inhibitors (HDIs) in combination with hormonal therapies.
In this paper, we will describe these different aspects and underline the clinical interest of HDIs in the context of breast cancer resistance to hormone therapies (HTs).
American Psychological Association (APA)
Linares, Aurélien& Dalenc, Florence& Balaguer, Patrick& Boulle, Nathalie& Cavailles, Vincent. 2010. Manipulating Protein Acetylation in Breast Cancer : A Promising Approach in Combination with Hormonal Therapies?. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-503777
Modern Language Association (MLA)
Linares, Aurélien…[et al.]. Manipulating Protein Acetylation in Breast Cancer : A Promising Approach in Combination with Hormonal Therapies?. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-503777
American Medical Association (AMA)
Linares, Aurélien& Dalenc, Florence& Balaguer, Patrick& Boulle, Nathalie& Cavailles, Vincent. Manipulating Protein Acetylation in Breast Cancer : A Promising Approach in Combination with Hormonal Therapies?. Journal of Biomedicine and Biotechnology. 2010. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-503777
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503777