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Zebrafish Thrombocytes : Functions and Origins
Joint Authors
Khandekar, Gauri
Kim, Seongcheol
Jagadeeswaran, Pudur
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Platelets play an important role in mammalian hemostasis.
Thrombocytes of early vertebrates are functionally equivalent to mammalian platelets.
A substantial amount of research has been done to study platelet function in humans as well as in animal models.
However, to date only limited functional genomic studies of platelets have been performed but are low throughput and are not cost-effective.
Keeping this in mind we introduced zebrafish, a vertebrate genetic model to study platelet function.
We characterized zebrafish thrombocytes and established functional assays study not only their hemostatic function but to also their production.
We identified a few genes which play a role in their function and production.
Since we introduced the zebrafish model for the study of hemostasis and thrombosis, other groups have adapted this model to study genes that are associated with thrombocyte function and a few novel genes have also been identified.
Furthermore, transgenic zebrafish with GFP-tagged thrombocytes have been developed which helped to study the production of thrombocytes and their precursors as well as their functional roles not only in hemostasis but also hematopoiesis.
This paper integrates the information available on zebrafish thrombocyte function and its formation.
American Psychological Association (APA)
Khandekar, Gauri& Kim, Seongcheol& Jagadeeswaran, Pudur. 2012. Zebrafish Thrombocytes : Functions and Origins. Advances in Hematology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-503781
Modern Language Association (MLA)
Khandekar, Gauri…[et al.]. Zebrafish Thrombocytes : Functions and Origins. Advances in Hematology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-503781
American Medical Association (AMA)
Khandekar, Gauri& Kim, Seongcheol& Jagadeeswaran, Pudur. Zebrafish Thrombocytes : Functions and Origins. Advances in Hematology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-503781
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503781