![](/images/graphics-bg.png)
Antenatal Bartter Syndrome : A Review
Joint Authors
Sreelakshmi, K.
Vinayaka, G.
Bhat, Y. Ramesh
Source
International Journal of Pediatrics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Antenatal Bartter syndrome (ABS) is a rare autosomal recessive renal tubular disorder.
The defective chloride transport in the loop of Henle leads to fetal polyuria resulting in severe hydramnios and premature delivery.
Early onset, unexplained maternal polyhydramnios often challenges the treating obstetrician.
Increasing polyhydramnios without apparent fetal or placental abnormalities should lead to the suspicion of this entity.
Biochemical analysis of amniotic fluid is suggested as elevated chloride level is usually diagnostic.
Awareness, early recognition, maternal treatment with indomethacin, and amniocentesis allow the pregnancy to continue.
Affected neonates are usually born premature, have postnatal polyuria, vomiting, failure to thrive, hypercalciuria, and subsequently nephrocalcinosis.
Hypokalemia, metabolic alkalosis, secondary hyperaldosteronism and hyperreninaemia are other characteristic features.
Volume depletion due to excessive salt and water loss on long term stimulates renin-angiotensin-aldosterone system resulting in juxtaglomerular hyperplasia.
Clinical features and electrolyte abnormalities may also depend on the subtype of the syndrome.
Prenatal diagnosis and timely indomethacin administration prevent electrolyte imbalance, restitute normal growth, and improve activity.
In this paper, authors present classification, pathophysiology, clinical manifestations, laboratory findings, complications, and prognosis of ABS.
American Psychological Association (APA)
Bhat, Y. Ramesh& Vinayaka, G.& Sreelakshmi, K.. 2012. Antenatal Bartter Syndrome : A Review. International Journal of Pediatrics،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-503791
Modern Language Association (MLA)
Bhat, Y. Ramesh…[et al.]. Antenatal Bartter Syndrome : A Review. International Journal of Pediatrics No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-503791
American Medical Association (AMA)
Bhat, Y. Ramesh& Vinayaka, G.& Sreelakshmi, K.. Antenatal Bartter Syndrome : A Review. International Journal of Pediatrics. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-503791
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503791