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Anti-Inflammatory Effects and Mechanisms of Fatsia polycarpa Hayata and Its Constituents
Joint Authors
Nurkholis,
Huang, Shen-Da
Cheng, Hsueh-Ling
Wang, Xiao-Wen
Lu, Yan-Ting
Cheng, Shi-Yie
Chou, Chang-Hung
Liu, Yu-Liang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Fatsia polycarpa, a plant endemic to Taiwan, is an herbal medicine known for treating several inflammation-related diseases, but its biological function needs scientific support.
Thus, the anti-inflammatory effects and mechanisms of the methanolic crude extract (MCE) of F.
polycarpa and its feature constituents, that is, brassicasterol (a phytosterol), triterpenoids 3α-hydroxyolean-11,13(18)-dien-28-oic acid (HODA), 3α-hydroxyolean-11-en-28,13β-olide (HOEO), fatsicarpain D, and fatsicarpain F, were investigated.
MCE and HOEO, but not brassicasterol, dose-dependently inhibited lipopolysaccharide- (LPS-)induced expression of inducible nitric oxide synthase and cyclooxygenase-2 in RAW 264.7 macrophage line, whereas HODA, fatsicarpain D and fatsicarpain F were toxic to RAW cells.
Additionally, MCE and HOEO suppressed LPS-induced production of nitric oxide, prostaglandin E2, and interleukin-1β and interfered with LPS-promoted activation of the inhibitor kappa B kinase (IKK)/nuclear factor-κB (NF-κB) pathway, and that of the mitogen-activated protein kinases (MAPKs) extracellular signal regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38.
In animal tests, MCE and HOEO effectively ameliorated 12-O-tetradecanoylphorobol-13 acetate- (TPA-)induced ear edema of mice.
Thus, MCE of F.
polycarpa exhibited an obvious anti-inflammatory activity in vivo and in vitro that likely involved the inhibition of the IKK/NF-κB pathway and the MAPKs, which may be attributed by triterpenoids such as HOEO.
American Psychological Association (APA)
Cheng, Hsueh-Ling& Nurkholis, & Cheng, Shi-Yie& Huang, Shen-Da& Lu, Yan-Ting& Wang, Xiao-Wen…[et al.]. 2013. Anti-Inflammatory Effects and Mechanisms of Fatsia polycarpa Hayata and Its Constituents. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-503801
Modern Language Association (MLA)
Cheng, Hsueh-Ling…[et al.]. Anti-Inflammatory Effects and Mechanisms of Fatsia polycarpa Hayata and Its Constituents. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-503801
American Medical Association (AMA)
Cheng, Hsueh-Ling& Nurkholis, & Cheng, Shi-Yie& Huang, Shen-Da& Lu, Yan-Ting& Wang, Xiao-Wen…[et al.]. Anti-Inflammatory Effects and Mechanisms of Fatsia polycarpa Hayata and Its Constituents. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-503801
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503801