Protein Kinase C-Regulated Aβ Production and Clearance
Joint Authors
Choi, Doo-Sup
Hinton, David J.
Kim, Taehyun
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is the most common form of dementia among the elderly population.
AD, which is characterized as a disease of cognitive deficits, is mainly associated with an increase of amyloid β-peptide (Aβ) in the brain.
A growing body of recent studies suggests that protein kinase C (PKC) promotes the production of the secretory form of amyloid precursor protein (sAPPα) via the activation of α-secretase activity, which reduces the accumulation of pathogenic Aβ levels in the brain.
Moreover, activation of PKCα and mitogen-activated protein kinase (MAPK) is known to increase sAPPα.
A novel type of PKC, PKCε, activates the Aβ degrading activity of endothelin converting enzyme type 1 (ECE-1), which might be mediated via the MAPK pathway as well.
Furthermore, dysregulation of PKC-MAPK signaling is known to increase Aβ levels in the brain, which results in AD phenotypes.
Here, we discuss roles of PKC in Aβ production and clearance and its implication in AD.
American Psychological Association (APA)
Kim, Taehyun& Hinton, David J.& Choi, Doo-Sup. 2011. Protein Kinase C-Regulated Aβ Production and Clearance. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-503811
Modern Language Association (MLA)
Kim, Taehyun…[et al.]. Protein Kinase C-Regulated Aβ Production and Clearance. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-503811
American Medical Association (AMA)
Kim, Taehyun& Hinton, David J.& Choi, Doo-Sup. Protein Kinase C-Regulated Aβ Production and Clearance. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-503811
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503811