Expression of VEGF-A, Otx Homeobox and p53 Family Genes in Proliferative Vitreoretinopathy
Joint Authors
Azzolini, Claudio
Vinciguerra, Riccardo
Simonelli, Francesca
Chiaravalli, Anna Maria
Borroni, Davide
Pirrone, Cristina
Porta, Giovanni
Donati, Simone
al-Oum, Muna
Pagani, Ilaria Stefania
Pigni, Diana
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Proliferative vitreoretinopathy (PVR) is a severe inflammatory complication of retinal detachment.
Pathological epiretinal membranes grow on the retina surface leading to contraction, and surgery fails in 5% to 10% of the cases.
We evaluated the expression of VEGF-A, Otx1, Otx2, Otx3, and p53 family members from PVR specimens to correlate their role in inducing or preventing the pathology.
Methods.
Twelve retinal samples were taken from patients affected by PVR during therapeutic retinectomies in vitreoretinal surgery.
Gene expression was evaluated using quantitative real-time reverse transcriptase PCR analysis and immunohistochemistry, using four healthy human retinae as control.
Result.
Controls showed basal expression of all genes.
PVR samples showed little or no expression of Otx1 and variable expression of VEGF-A, Otx2, Otx3, p53, and p63 genes.
Significant correlation was found among VEGF-A, Otx2, p53, and p63 and between Otx1 and Otx3.
Conclusions.
Otx homeobox, p53 family, and VEGF-A genes are expressed in PVR human retina.
We individuated two possible pathways (VEGF-A, Otx2, p53, p63 and Otx1 and Otx3) involved in PVR progression that could influence in different manners the course of the pathology.
Individuating the genetic pathways of PVR represents a novel approach to PVR therapies.
American Psychological Association (APA)
Azzolini, Claudio& Pagani, Ilaria Stefania& Pirrone, Cristina& Borroni, Davide& Donati, Simone& al-Oum, Muna…[et al.]. 2013. Expression of VEGF-A, Otx Homeobox and p53 Family Genes in Proliferative Vitreoretinopathy. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-503814
Modern Language Association (MLA)
Azzolini, Claudio…[et al.]. Expression of VEGF-A, Otx Homeobox and p53 Family Genes in Proliferative Vitreoretinopathy. Mediators of Inflammation No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-503814
American Medical Association (AMA)
Azzolini, Claudio& Pagani, Ilaria Stefania& Pirrone, Cristina& Borroni, Davide& Donati, Simone& al-Oum, Muna…[et al.]. Expression of VEGF-A, Otx Homeobox and p53 Family Genes in Proliferative Vitreoretinopathy. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-503814
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503814