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Moderate Intra-Abdominal Hypertension Leads to Anaerobic Metabolism in the Rectus Abdominis Muscle Tissue of Critically Ill Patients : A Prospective Observational Study
Joint Authors
Kirsimägi, Ülle
Starkopf, Joel
Maddison, Liivi
Karjagin, Juri
Tenhunen, Jyrki
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
We hypothesize that intra-abdominal hypertension (IAH) is associated with the presence of anaerobic metabolism in the abdominal rectus muscle (RAM) tissue of critically ill patients.
Methods.
We included 10 adult, critically ill patients with intra-abdominal pressure (IAP) above 12 mmHg.
Microdialysis catheters (CMA 60) were inserted into the RAM tissue.
The samples were collected up to 72 hours after enrollment.
Results.
The patients’ median (IQR) APACHE II at inclusion was 29 (21–37); 7 patients were in shock.
IAP was 14.5 (12.5–17.8) mmHg at baseline and decreased significantly over time, concomitantly with arterial lactate and vasopressors requirements.
The tissue lactate-to-pyruvate (L/P) ratio was 49 (36–54) at the beginning of the study and decreased significantly throughout the study.
Additionally, the tissue lactate, lactate-to-glucose (L/G) ratio, and glutamate concentrations changed significantly during the study.
The correlation analysis showed that lower levels of pyruvate and glycerol were associated with higher MAP and abdominal perfusion pressures (APP) and that higher levels of glutamate were correlated to elevated IAP.
Conclusions.
Moderate IAH leads to RAM tissue anaerobic metabolism suggestive for hypoperfusion in critically ill patients.
Correlation analysis supports the concept of using APP as the primary endpoint of resuscitation in addition to MAP and IAP.
American Psychological Association (APA)
Maddison, Liivi& Karjagin, Juri& Tenhunen, Jyrki& Kirsimägi, Ülle& Starkopf, Joel. 2014. Moderate Intra-Abdominal Hypertension Leads to Anaerobic Metabolism in the Rectus Abdominis Muscle Tissue of Critically Ill Patients : A Prospective Observational Study. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-503827
Modern Language Association (MLA)
Maddison, Liivi…[et al.]. Moderate Intra-Abdominal Hypertension Leads to Anaerobic Metabolism in the Rectus Abdominis Muscle Tissue of Critically Ill Patients : A Prospective Observational Study. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-503827
American Medical Association (AMA)
Maddison, Liivi& Karjagin, Juri& Tenhunen, Jyrki& Kirsimägi, Ülle& Starkopf, Joel. Moderate Intra-Abdominal Hypertension Leads to Anaerobic Metabolism in the Rectus Abdominis Muscle Tissue of Critically Ill Patients : A Prospective Observational Study. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-503827
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503827