Adult BMI Change and Risk of Colon Cancer in Postmenopausal Women
Joint Authors
Chen, Zhengyi
Berger, Nathan A.
Thompson, Cheryl L.
Tucker, Thomas C.
Li, Li
Blake-Gumbs, Lyla
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
We recently reported an association of adult BMI change with colon cancer risk.
Here, we sought to further explore this association with respect to postmenopausal HRT use in a larger study population.
Methods.
We included 1,457 postmenopausal women participating in an ongoing population-based case-control study of colon cancer.
Results.
We confirmed a previously reported association of adulthood weight gain and increased risk of colon cancer: compared to those with <5 kg/m2 change of BMI, women who reported moderate (5–10 kg/m2) and large (>10 kg/m2) BMI changes since their 20s had OR estimates of 1.54 (95% CI = 1.09–2.19) and 1.45 (95% CI = 0.90–2.33), respectively (P for trend = 0.05).
Stratified analyses showed that this association was limited to HRT nonusers: ORs were 1.77 (95% CI = 1.02–3.05) and 2.21 (95% CI = 1.09–4.45), respectively (P for trend = 0.03), for BMI changes occurring between the 20s decade and time of recruitment among non-users.
Similar associations were observed for BMI changes since the 30s decade.
There was no association among HRT users.
Conclusion.
Our results suggest early adulthood weight gain increases colon cancer risk in postmenopausal women who do not use HRT.
American Psychological Association (APA)
Blake-Gumbs, Lyla& Chen, Zhengyi& Thompson, Cheryl L.& Berger, Nathan A.& Tucker, Thomas C.& Li, Li. 2012. Adult BMI Change and Risk of Colon Cancer in Postmenopausal Women. Journal of Obesity،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-503831
Modern Language Association (MLA)
Blake-Gumbs, Lyla…[et al.]. Adult BMI Change and Risk of Colon Cancer in Postmenopausal Women. Journal of Obesity No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-503831
American Medical Association (AMA)
Blake-Gumbs, Lyla& Chen, Zhengyi& Thompson, Cheryl L.& Berger, Nathan A.& Tucker, Thomas C.& Li, Li. Adult BMI Change and Risk of Colon Cancer in Postmenopausal Women. Journal of Obesity. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-503831
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503831