A Case of Subacute Cutaneous Lupus Erythematosus in a Patient with Mixed Connective Tissue Disease : Successful Treatment with Plasmapheresis and Rituximab
Joint Authors
Salemi, S.
Fantò, M.
Socciarelli, F.
Natale, G. A.
Di Rosa, R.
Casorelli, I.
D'Amelio, R.
Bartolazzi, A.
Pavan, A.
Vaglio, S.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-28
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
A 30-year-old woman affected by Mixed Connective Tissue Disease with scleroderma spectrum developed a facial eruption, a clinical and histological characteristic of subacute cutaneous lupus erythematosus (SCLE).
Speckled anti-nuclear antibodies, high-titer anti-ribonucleoprotein1, anti-Sm, anti-Cardiolipin (aCL) IgG/IgM, and anti-Ro/SSA antibodies were positive.
SCLE was resistant to Azathioprine, Hydroxychloroquine, and Methotrexate while Mycophenolate Mofetil was suspended due to side effects.
Subsequently, the patient was treated with three cycles of therapeutic plasma exchange (TPE) followed, one month after the last TPE, by the anti-CD20 antibody Rituximab (RTX) (375 mg/m2 weekly for 4 weeks).
Eight and 16 months later the patient received other two TPE and RTX cycles, respectively.
This therapeutic approach has allowed to obtain a complete skin healing persistent even after 8-month follow-up.
Moreover, mitigation of Raynaud's phenomenon, resolution of alopecia, and a decline of aCL IgG/IgM and anti-Ro/SSA antibodies were observed.
American Psychological Association (APA)
Fantò, M.& Salemi, S.& Socciarelli, F.& Bartolazzi, A.& Natale, G. A.& Casorelli, I.…[et al.]. 2013. A Case of Subacute Cutaneous Lupus Erythematosus in a Patient with Mixed Connective Tissue Disease : Successful Treatment with Plasmapheresis and Rituximab. Case Reports in Rheumatology،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-503849
Modern Language Association (MLA)
Fantò, M.…[et al.]. A Case of Subacute Cutaneous Lupus Erythematosus in a Patient with Mixed Connective Tissue Disease : Successful Treatment with Plasmapheresis and Rituximab. Case Reports in Rheumatology No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-503849
American Medical Association (AMA)
Fantò, M.& Salemi, S.& Socciarelli, F.& Bartolazzi, A.& Natale, G. A.& Casorelli, I.…[et al.]. A Case of Subacute Cutaneous Lupus Erythematosus in a Patient with Mixed Connective Tissue Disease : Successful Treatment with Plasmapheresis and Rituximab. Case Reports in Rheumatology. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-503849
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503849