Clinicopathological Comparison of Adenocarcinoma of Cervix and Endometrium Using Cell Cycle Markers : P16ink4a, P21waf1, and p27Kip1 on 132 Cancers
Joint Authors
Othman, Nor Hayati
Nik Mustapha, Nik Raihan
Marican Abu Backer, Farveen
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
We studied the clinicopathological parameters of adenocarcinoma arising from endocervix (ECA) and from endometrium (EMA) based on the expression of P16ink4a, P21waf1, and p27Kip1 proteins.
Study Design.
Immunohistochemistry was done on sections of confirmed ECA and EMA from hysterectomy specimens which have had no prior chemotherapy/radiotherapy.
Results.
There were 40 ECAs and 92 EMAs.
The mean age of ECA was 49.82 (SD 10.29); the youngest was 30 years old and the oldest 75 years old.
The mean age of EMA was 54.45 (SD 10.92); the youngest was 30 years old and the oldest was 82 years old.
For ECA, the size of the tumour is significantly associated with age and with depth of infiltration.
FIGO stage is associated with histological grade.
p21WAF1 expression is significantly associated with infiltration of the corpus and lymph node metastasis.
p27Kip1 expression is significantly associated with lymph node invasion.
The presence of lymph node metastasis is strongly associated when p16INK4a and p27Kip1 expressions are analyzed in combination.
For EMA, p16INK4a expression is associated with histologic grade.
Conclusion.
Our study shows that we could use these cell cycle markers as predictors for more aggressive subsets of adenocarcinoma of the cervix and endometrium.
American Psychological Association (APA)
Marican Abu Backer, Farveen& Nik Mustapha, Nik Raihan& Othman, Nor Hayati. 2011. Clinicopathological Comparison of Adenocarcinoma of Cervix and Endometrium Using Cell Cycle Markers : P16ink4a, P21waf1, and p27Kip1 on 132 Cancers. Infectious Diseases in Obstetrics and Gynecology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-503858
Modern Language Association (MLA)
Marican Abu Backer, Farveen…[et al.]. Clinicopathological Comparison of Adenocarcinoma of Cervix and Endometrium Using Cell Cycle Markers : P16ink4a, P21waf1, and p27Kip1 on 132 Cancers. Infectious Diseases in Obstetrics and Gynecology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-503858
American Medical Association (AMA)
Marican Abu Backer, Farveen& Nik Mustapha, Nik Raihan& Othman, Nor Hayati. Clinicopathological Comparison of Adenocarcinoma of Cervix and Endometrium Using Cell Cycle Markers : P16ink4a, P21waf1, and p27Kip1 on 132 Cancers. Infectious Diseases in Obstetrics and Gynecology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-503858
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503858