Single Diabetic QTL Derived from OLETF Rat Is a Sufficient Agent for Severe Diabetic Phenotype in Combination with Leptin-Signaling Deficiency
Joint Authors
Matsumoto, Kozo
Kose, Hiroyuki
Yamada, Takahisa
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Obesity has been considered one of the leading causative agents for diseases such as type 2 diabetes, stroke, and heart attack.
Due to their complex etiology, establishing auseful animal model is increasingly crucial for better molecular understanding of how obesity influences on disease development.
OLETF rat is a spontaneous model of type 2 diabetes.
We mapped 14 hyperglycemia QTLs in the genome of the OLETF rat and subsequently generated a panel of congenic strains each possessing OB-R mutation in F344 genetic background.
Here we show that one of the loci, Nidd2/of, is highly responsive to obesity.
When leptin receptor mutation is introgressed into the Nidd2/of congenic strain, the rat showed hyperglycemia equivalent to that of the parental OLETF rat.
This suggests that the Nidd2/of locus has a strong genetic interaction with leptin signaling pathway.
Furthermore, when another hyperglycemia QTL Nidd1/of is additionally combined, the strain developed overt diabetes.
A single QTL dissected out in spontaneous model normally exerts only mild effect on the quantitative trait, which makes it difficult to clone the gene.
Our new model may help not only to identify the causative gene but also to investigate how obesity interacts with a QTL to regulate diabetic traits.
American Psychological Association (APA)
Kose, Hiroyuki& Yamada, Takahisa& Matsumoto, Kozo. 2012. Single Diabetic QTL Derived from OLETF Rat Is a Sufficient Agent for Severe Diabetic Phenotype in Combination with Leptin-Signaling Deficiency. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-503888
Modern Language Association (MLA)
Kose, Hiroyuki…[et al.]. Single Diabetic QTL Derived from OLETF Rat Is a Sufficient Agent for Severe Diabetic Phenotype in Combination with Leptin-Signaling Deficiency. Experimental Diabetes Research No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-503888
American Medical Association (AMA)
Kose, Hiroyuki& Yamada, Takahisa& Matsumoto, Kozo. Single Diabetic QTL Derived from OLETF Rat Is a Sufficient Agent for Severe Diabetic Phenotype in Combination with Leptin-Signaling Deficiency. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-503888
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503888