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Dynamics of Blood Count after Rheohemapheresis in Age-Related Macular Degeneration : Possible Association with Clinical Changes
Joint Authors
Rencová, Eva
Langrová, Hana
Kratochvilová, Vera
Lánská, Miriam
Bláha, Milan
Košťál, Milan
Rozsíval, Pavel
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-06
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Rheohemapheresis (RHF) is a method that can stop the activity of the dry form of age-related macular degeneration (AMD).
The pathophysiologic mechanisms are not well understood, and the effects of the RHF procedures extend beyond the time of the individual procedures.
Patients and Methods.
We present the data for 46 patients with AMD treated with a series of 8 rheohemapheretic procedures.
Blood count parameters were measured before the first and the last procedures.
The clinical effect was judged by changes in the drusenoid pigment epithelium detachment (DPED) area before and after the rheopheretic sessions.
Results.
Rheopheresis caused a decrease in hemoglobin (P<0.001), a decrease in leukocytes (P<0.034), and an increase in platelets (P<0.005).
We found a negative correlation between the amount of platelets and their volume (P<0.001, Pearson correlation coefficient: −0.509).
We identified the platelet/MPV ratio as a good predictor of the clinical outcome.
Patients with a platelet/MPV ratio greater than 21.5 (before the last rheopheresis) had a significantly better outcome (P=0.003, sensitivity of 76.9% and specificity of 80%).
Conclusion.
Several basic blood count parameters after RHF can be concluded to significantly change, with some of those changes correlating with the clinical results (reduction of the DPED area).
American Psychological Association (APA)
Košťál, Milan& Bláha, Milan& Rencová, Eva& Lánská, Miriam& Rozsíval, Pavel& Kratochvilová, Vera…[et al.]. 2014. Dynamics of Blood Count after Rheohemapheresis in Age-Related Macular Degeneration : Possible Association with Clinical Changes. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-503897
Modern Language Association (MLA)
Košťál, Milan…[et al.]. Dynamics of Blood Count after Rheohemapheresis in Age-Related Macular Degeneration : Possible Association with Clinical Changes. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-503897
American Medical Association (AMA)
Košťál, Milan& Bláha, Milan& Rencová, Eva& Lánská, Miriam& Rozsíval, Pavel& Kratochvilová, Vera…[et al.]. Dynamics of Blood Count after Rheohemapheresis in Age-Related Macular Degeneration : Possible Association with Clinical Changes. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-503897
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503897