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Apocynin Improves Insulin Resistance through Suppressing Inflammation in High-Fat Diet-Induced Obese Mice
Joint Authors
Bi, Yan
Zhu, Da-Long
Meng, Ran
Yang, Dong-Hui
Wang, Ya-Ping
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We investigated the effects of apocynin on high-fat diet- (HFD-) induced insulin resistance in C57BL/6 mice.
After 12 weeks of HFD, the mice that exhibited insulin resistance then received 5 weeks of apocynin (2.4 g/L, in water).
Following apocynin treatment, fasting glucose, insulin, and glucose tolerance test showed significant improvement in insulin sensitivity in HFD-fed mice.
We demonstrated that serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and leptin were remarkably reduced with apocynin treatment.
We also found that mRNA expression of TNF-α, IL-6, and monocyte chemoattractant protein-1 (MCP-1) in the liver and mRNA expression of TNF-α, IL-6, MCP-1, and leptin in adipose tissue were suppressed by apocynin.
Furthermore, the activity of transcription factor NF-κB in the liver was significantly suppressed with apocynin treatment.
These results suggest that apocynin may reduce inflammatory factors in the blood, liver, and adipose tissue, resulting in amelioration of insulin resistance in HFD-fed mice.
American Psychological Association (APA)
Meng, Ran& Zhu, Da-Long& Bi, Yan& Yang, Dong-Hui& Wang, Ya-Ping. 2011. Apocynin Improves Insulin Resistance through Suppressing Inflammation in High-Fat Diet-Induced Obese Mice. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-503943
Modern Language Association (MLA)
Meng, Ran…[et al.]. Apocynin Improves Insulin Resistance through Suppressing Inflammation in High-Fat Diet-Induced Obese Mice. Mediators of Inflammation No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-503943
American Medical Association (AMA)
Meng, Ran& Zhu, Da-Long& Bi, Yan& Yang, Dong-Hui& Wang, Ya-Ping. Apocynin Improves Insulin Resistance through Suppressing Inflammation in High-Fat Diet-Induced Obese Mice. Mediators of Inflammation. 2011. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-503943
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503943