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Evaluation of Anti-Inflammatory Activity of Citrus latifolia Tanaka Essential Oil and Limonene in Experimental Mouse Models
Joint Authors
Grespan, Renata
Estevão-Silva, Camila Fernanda
Kummer, Raquel
Cuman, Roberto Kenji Nakamura
Silva, Expedito Leite
Fachini-Queiroz, Fernanda Carolina
Bersani-Amado, Ciomar Aparecida
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The genus Citrus (Rutaceae) includes several species of plants that produce some of the most cultivated fruits in the world, providing an appreciable content of essential oil.
In folk medicine, they are used as a cholagogue, antipyretic, anti-inflammatory, sedative, and antitoxic effects.
Lemon essential oil has been used since ancient times for its antiseptic, carminative, diuretic, and eupeptic effects.
In this study, we investigated the anti-inflammatory activity of Citrus latifolia Tanaka essential oil (CLEO) and its main constituent LIM.
In the cell viability assay, CLEO and LIM (3, 10, 30, and 90 μg/mL) had low cytotoxicity.
In zymosan-induced peritonitis, LIM (500 mg/kg) decreased the infiltration of peritoneal exudate leukocytes and decreased the number of polymorphonuclear leukocytes.
In vitro chemotaxis revealed that CLEO and LIM (1, 3, and 10 µg/mL) promoted a significant reduction of neutrophil migration toward fMLP and LTB4.
LIM (500 mg/kg) also reduced TNF-α levels but did not alter IL-10 levels in the peritoneal exudate.
In conclusion, this study showed that LIM isolated from CLEO had potential anti-inflammatory effects, likely by inhibiting proinflammatory mediators present in inflammatory exudate and leukocyte chemotaxis.
American Psychological Association (APA)
Kummer, Raquel& Fachini-Queiroz, Fernanda Carolina& Estevão-Silva, Camila Fernanda& Grespan, Renata& Silva, Expedito Leite& Bersani-Amado, Ciomar Aparecida…[et al.]. 2013. Evaluation of Anti-Inflammatory Activity of Citrus latifolia Tanaka Essential Oil and Limonene in Experimental Mouse Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-503964
Modern Language Association (MLA)
Kummer, Raquel…[et al.]. Evaluation of Anti-Inflammatory Activity of Citrus latifolia Tanaka Essential Oil and Limonene in Experimental Mouse Models. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-503964
American Medical Association (AMA)
Kummer, Raquel& Fachini-Queiroz, Fernanda Carolina& Estevão-Silva, Camila Fernanda& Grespan, Renata& Silva, Expedito Leite& Bersani-Amado, Ciomar Aparecida…[et al.]. Evaluation of Anti-Inflammatory Activity of Citrus latifolia Tanaka Essential Oil and Limonene in Experimental Mouse Models. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-503964
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503964