Sex Differences in the Association between Level of Childhood Interleukin-6 and Insulin Resistance in Adolescence

Abstract EN

The purpose of this study was to determine whether levels of interleukin-6 (IL-6) in childhood are related to insulin resistance in adolescence.

Further, to explore how fatness and cardiorespiratory fitness (VO2peak) moderate this relationship.

Methods.

292 nine-year-old children (n=292) were followed for 4 years.

Anthropometrics and VO2peak were measured.

Fasting blood samples were analyzed for IL-6, insulin, and glucose.

Homeostasis model assessment (HOMA-IR) was used as a measure of insulin resistance.

Results.

For girls but not boys, levels of IL-6 at age 9 yrs correlated with HOMA-IR at age 13 yrs: r=0.223, P=0.008.

Girls with IL-6 levels within the highest quartile at age 9 yrs had an odds ratio of 3.68 (CI = 1.58–8.57) being in the highest quartile of HOMA-IR four years later.

Conclusion.

In this cohort, IL-6 levels in childhood were related to insulin resistance in adolescence, but only for girls.