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Antinociceptive Activity of Ethanol Extract from Duguetia chrysocarpa Maas (Annonaceae)
Joint Authors
Barbosa Filho, José Maria
Agra, Maria de Fátima
Nunes, Xirley Pereira
Araújo, Edigênia Cavalcante da Cruz
Lúcio, Ana Sílvia Suassuna Carneiro
Almeida, Jackson Roberto Guedes da Silva
de Lima, Julianeli Tolentino
Ribeiro, Luciano Augusto de Araújo
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
The ethanol extract from the fruits of Duguetia chrysocarpa was evaluated for its antinociceptive activity in chemical and thermal models of nociception in mice.
The intraperitoneal administration of the ethanol extract (100, 200, and 400 mg/kg body weight) showed a dose-dependent inhibition of acetic-acid-induced abdominal writhes.
The extract also produced a significant inhibition of both phases of the formalin test in all doses tested and increased the reaction time in hot-plate test at dose of 200 mg/kg.
The data obtained suggest that the antinociceptive effect of the extract may be mediated via both peripheral and central mechanisms.
The phytochemical investigation yielded the isolation of the benzenoid derivative 3-methoxy-4-ethoxy benzoic acid which is being reported for the first time in this genus.
American Psychological Association (APA)
Almeida, Jackson Roberto Guedes da Silva& Araújo, Edigênia Cavalcante da Cruz& Ribeiro, Luciano Augusto de Araújo& de Lima, Julianeli Tolentino& Nunes, Xirley Pereira& Lúcio, Ana Sílvia Suassuna Carneiro…[et al.]. 2012. Antinociceptive Activity of Ethanol Extract from Duguetia chrysocarpa Maas (Annonaceae). The Scientific World Journal،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-503974
Modern Language Association (MLA)
Almeida, Jackson Roberto Guedes da Silva…[et al.]. Antinociceptive Activity of Ethanol Extract from Duguetia chrysocarpa Maas (Annonaceae). The Scientific World Journal No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-503974
American Medical Association (AMA)
Almeida, Jackson Roberto Guedes da Silva& Araújo, Edigênia Cavalcante da Cruz& Ribeiro, Luciano Augusto de Araújo& de Lima, Julianeli Tolentino& Nunes, Xirley Pereira& Lúcio, Ana Sílvia Suassuna Carneiro…[et al.]. Antinociceptive Activity of Ethanol Extract from Duguetia chrysocarpa Maas (Annonaceae). The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-503974
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503974