Multilocus Family-Based Association Analysis of Seven Candidate Polymorphisms with Essential Hypertension in an African-Derived Semi-Isolated Brazilian Population
Joint Authors
Angeli, C. B.
Pereira, T. V.
Mingroni-Netto, R. C.
Auricchio, M. T. B. M.
Fernandes, G. R.
Vicente, J. P.
Pereira, A. C.
Kimura, L.
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
It has been widely suggested that analyses considering multilocus effects would be crucial to characterize the relationship between gene variability and essential hypertension (EH).
Objective.
To test for the presence of multilocus effects between/among seven polymorphisms (six genes) on blood pressure-related traits in African-derived semi-isolated Brazilian populations (quilombos).
Methods.
Analyses were carried out using a family-based design in a sample of 652 participants (97 families).
Seven variants were investigated: ACE (rs1799752), AGT (rs669), ADD2 (rs3755351), NOS3 (rs1799983), GNB3 (rs5441 and rs5443), and GRK4 (rs1801058).
Sensitivity analyses were further performed under a case-control design with unrelated participants only.
Results.
None of the investigated variants were associated individually with both systolic and diastolic BP levels (SBP and DBP, respectively) or EH (as a binary outcome).
Multifactor dimensionality reduction-based techniques revealed a marginal association of the combined effect of both GNB3 variants on DBP levels in a family-based design (P=0.040), whereas a putative NOS3-GRK4 interaction also in relation to DBP levels was observed in the case-control design only (P=0.004).
Conclusion.
Our results provide limited support for the hypothesis of multilocus effects between/among the studied variants on blood pressure in quilombos.
Further larger studies are needed to validate our findings.
American Psychological Association (APA)
Kimura, L.& Angeli, C. B.& Auricchio, M. T. B. M.& Fernandes, G. R.& Pereira, A. C.& Vicente, J. P.…[et al.]. 2012. Multilocus Family-Based Association Analysis of Seven Candidate Polymorphisms with Essential Hypertension in an African-Derived Semi-Isolated Brazilian Population. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-503977
Modern Language Association (MLA)
Kimura, L.…[et al.]. Multilocus Family-Based Association Analysis of Seven Candidate Polymorphisms with Essential Hypertension in an African-Derived Semi-Isolated Brazilian Population. International Journal of Hypertension No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-503977
American Medical Association (AMA)
Kimura, L.& Angeli, C. B.& Auricchio, M. T. B. M.& Fernandes, G. R.& Pereira, A. C.& Vicente, J. P.…[et al.]. Multilocus Family-Based Association Analysis of Seven Candidate Polymorphisms with Essential Hypertension in an African-Derived Semi-Isolated Brazilian Population. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-503977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503977