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Deafferentation-Induced Redistribution of MMP-2, but Not of MMP-9, Depends on the Emergence of GAP-43 Positive Axons in the Adult Rat Cochlear Nucleus
Joint Authors
Fredrich, Michaela
Illing, Robert-Benjamin
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-23
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The matrix metalloproteinases MMP-9 and MMP-2, major modulators of the extracellular matrix (ECM), were changed in amount and distribution in the rat anteroventral cochlear nucleus (AVCN) following its sensory deafferentation by cochlear ablation.
To determine what causal relationships exist between the redistribution of MMP-9 and MMP-2 and deafferentation-induced reinnervation, kainic acid was stereotaxically injected into the ventral nucleus of the trapezoid body (VNTB) prior to cochlear ablation, killing cells that deliver the growth associated protein 43 (GAP-43) into AVCN.
Deafferentation-induced changes in the pattern of MMP-9 staining remained unaffected by VNTB lesions.
By contrast, changes in the distribution of MMP-2 normally evoked by sensory deafferentation were reversed if GAP-43 positive axons were prevented to grow in AVCN.
In conclusion, GAP-43-containing axons emerging in AVCN after cochlear ablation seem to be causal for the maintenance of MMP-2-mediated ECM remodeling.
American Psychological Association (APA)
Fredrich, Michaela& Illing, Robert-Benjamin. 2011. Deafferentation-Induced Redistribution of MMP-2, but Not of MMP-9, Depends on the Emergence of GAP-43 Positive Axons in the Adult Rat Cochlear Nucleus. Neural Plasticity،Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-503992
Modern Language Association (MLA)
Fredrich, Michaela& Illing, Robert-Benjamin. Deafferentation-Induced Redistribution of MMP-2, but Not of MMP-9, Depends on the Emergence of GAP-43 Positive Axons in the Adult Rat Cochlear Nucleus. Neural Plasticity No. 2011 (2011), pp.1-17.
https://search.emarefa.net/detail/BIM-503992
American Medical Association (AMA)
Fredrich, Michaela& Illing, Robert-Benjamin. Deafferentation-Induced Redistribution of MMP-2, but Not of MMP-9, Depends on the Emergence of GAP-43 Positive Axons in the Adult Rat Cochlear Nucleus. Neural Plasticity. 2011. Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-503992
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503992