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A Comparison of Inflammatory and Oxidative Stress Markers in Adipose Tissue from Weight-Matched Obese Male and Female Mice
Joint Authors
Nickelson, Karen J.
Perfield, James W.
Stromsdorfer, Kelly L.
Liu, Tzu-Wen
Ortinau, Laura C.
Keating, Aileen F.
Pickering, R. Taylor
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Expansion of intra-abdominal adipose tissue and the accompanying inflammatory response has been put forward as a unifying link between obesity and the development of chronic diseases.
However, an apparent sexual dimorphism exists between obesity and chronic disease risk due to differences in the distribution and abundance of adipose tissue.
A range of experimental protocols have been employed to demonstrate the role of estrogen in regulating health benefits; however, most studies are confounded by significant differences in body weight and adiposity.
Therefore, the purpose of this study was to compare weight-matched obese male and female mice to determine if the sex-dependent health benefits remain when body weight is similar.
The development of obesity in female mice receiving a high-fat diet was delayed; however, subsequent comparisons of weight-matched obese mice revealed greater adiposity in obese female mice.
Despite excess adiposity and enlarged adipocyte size, obese females remained more glucose tolerant than weight-matched male mice, and this benefit was associated with increased expression of adiponectin and reductions in immune cell infiltration and oxidative stress in adipose tissue.
Therefore, the protective benefits of estrogen persist in the obese state and appear to improve the metabolic phenotype of adipose tissue and the individual.
American Psychological Association (APA)
Nickelson, Karen J.& Stromsdorfer, Kelly L.& Pickering, R. Taylor& Liu, Tzu-Wen& Ortinau, Laura C.& Keating, Aileen F.…[et al.]. 2012. A Comparison of Inflammatory and Oxidative Stress Markers in Adipose Tissue from Weight-Matched Obese Male and Female Mice. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-503995
Modern Language Association (MLA)
Nickelson, Karen J.…[et al.]. A Comparison of Inflammatory and Oxidative Stress Markers in Adipose Tissue from Weight-Matched Obese Male and Female Mice. Experimental Diabetes Research No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-503995
American Medical Association (AMA)
Nickelson, Karen J.& Stromsdorfer, Kelly L.& Pickering, R. Taylor& Liu, Tzu-Wen& Ortinau, Laura C.& Keating, Aileen F.…[et al.]. A Comparison of Inflammatory and Oxidative Stress Markers in Adipose Tissue from Weight-Matched Obese Male and Female Mice. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-503995
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503995