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Metabolism, Genomics, and DNA Repair in the Mouse Aging Liver
Joint Authors
Bohr, Vilhelm A.
de Souza-Pinto, Nadja C.
Lebel, Michel
Source
Current Gerontology and Geriatrics Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-06
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The liver plays a pivotal role in the metabolism of nutrients, drugs, hormones, and metabolic waste products, thereby maintaining body homeostasis.
The liver undergoes substantial changes in structure and function within old age.
Such changes are associated with significant impairment of many hepatic metabolic and detoxification activities, with implications for systemic aging and age-related disease.
It has become clear, using rodent models as biological tools, that genetic instability in the form of gross DNA rearrangements or point mutations accumulate in the liver with age.
DNA lesions, such as oxidized bases or persistent breaks, increase with age and correlate well with the presence of senescent hepatocytes.
The level of DNA damage and/or mutation can be affected by changes in carcinogen activation, decreased ability to repair DNA, or a combination of these factors.
This paper covers some of the DNA repair pathways affecting liver homeostasis with age using rodents as model systems.
American Psychological Association (APA)
Lebel, Michel& de Souza-Pinto, Nadja C.& Bohr, Vilhelm A.. 2011. Metabolism, Genomics, and DNA Repair in the Mouse Aging Liver. Current Gerontology and Geriatrics Research،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-504002
Modern Language Association (MLA)
Lebel, Michel…[et al.]. Metabolism, Genomics, and DNA Repair in the Mouse Aging Liver. Current Gerontology and Geriatrics Research No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-504002
American Medical Association (AMA)
Lebel, Michel& de Souza-Pinto, Nadja C.& Bohr, Vilhelm A.. Metabolism, Genomics, and DNA Repair in the Mouse Aging Liver. Current Gerontology and Geriatrics Research. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-504002
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504002