Angiogenesis and Endometriosis
Joint Authors
Taylor, Robert N.
Rocha, Ana Luiza L.
Reis, Fernando M.
Source
Obstetrics and Gynecology International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A comprehensive review was performed to survey the role of angiogenesis in the pathogenesis of endometriosis.
This is a multifactorial disease in which the development and maintenance of endometriotic implants depend on their invasive capacity and angiogenic potential.
The peritoneal fluid of patients with endometriosis is a complex suspension carrying inflammatory cytokines, growth factors, steroid hormones, proangiogenic factors, macrophages, and endometrial and red blood cells.
These cells and their signaling products concur to promote the spreading of new blood vessels at the endometriotic lesions and surroundings, which contributes to the endometriotic implant survival.
Experimental studies of several antiangiogenic agents demonstrated the regression of endometriotic lesions by reducing their blood supply.
Further studies are necessary before these novel agents can be introduced into clinical practice, in particular the establishment of the safety of anti-angiogenic medications in women who are seeking to become pregnant.
American Psychological Association (APA)
Rocha, Ana Luiza L.& Reis, Fernando M.& Taylor, Robert N.. 2013. Angiogenesis and Endometriosis. Obstetrics and Gynecology International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-504017
Modern Language Association (MLA)
Rocha, Ana Luiza L.…[et al.]. Angiogenesis and Endometriosis. Obstetrics and Gynecology International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-504017
American Medical Association (AMA)
Rocha, Ana Luiza L.& Reis, Fernando M.& Taylor, Robert N.. Angiogenesis and Endometriosis. Obstetrics and Gynecology International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-504017
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504017