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Antiadipogenic Effects of Aster glehni Extract : In Vivo and In Vitro Effects
Joint Authors
Kim, Myung-Dong
Yang, Gabsik
Park, Wansu
Lee, Heon-Myung
An, Hyo-Jin
Lee, Kyung-Tae
Nugroho, Agung
Ahn, Tae-Gue
Park, Hee-Juhn
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aster glehni (AG) is a Korean traditional herb that grows in Ulleungdo Island, Republic of Korea.
None of the several reports on AG include a determination of the effect of AG on adipogenesis.
The primary aim of this study was to determine whether AG attenuates adipogenesis in mouse 3T3-L1 cells and epididymal fat tissue.
AG blocked the differentiation of 3T3-L1 preadipocytes in a concentration-dependent manner and suppressed the expression of adipogenesis-related genes such as PPARγ, C/EBPα, and SREBP1c, the master regulators of adipogenesis.
Male C57BL/6J mice were divided randomly and equally into 4 diet groups: control diet (CON), high-fat diet (HFD), HFD with 1% AG extract added (AG1), and HFD with 5% AG extract added (AG5).
The experimental animals were fed HFD and the 2 combinations for 10 weeks.
Mice fed HFD with AG gained less body weight and visceral fat-pad weight than did the mice fed HFD alone.
Moreover, AG inhibited the expression of important adipogenic genes such as PPARγ, C/EBPα, SREBP1c, LXR, and leptin in the epididymal adipose tissue of the mice treated with AG1 and AG5.
These findings indicate antiadipogenic and antiobesity effects of AG and suggest its therapeutic potential in obesity and obesity-related diseases.
American Psychological Association (APA)
Lee, Heon-Myung& Yang, Gabsik& Ahn, Tae-Gue& Kim, Myung-Dong& Nugroho, Agung& Park, Hee-Juhn…[et al.]. 2013. Antiadipogenic Effects of Aster glehni Extract : In Vivo and In Vitro Effects. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-504018
Modern Language Association (MLA)
Lee, Heon-Myung…[et al.]. Antiadipogenic Effects of Aster glehni Extract : In Vivo and In Vitro Effects. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-504018
American Medical Association (AMA)
Lee, Heon-Myung& Yang, Gabsik& Ahn, Tae-Gue& Kim, Myung-Dong& Nugroho, Agung& Park, Hee-Juhn…[et al.]. Antiadipogenic Effects of Aster glehni Extract : In Vivo and In Vitro Effects. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-504018
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504018