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Time-Related Alteration in Flow- (Shear Stress-) Mediated Remodeling in Resistance Arteries from Spontaneously Hypertensive Rats
Joint Authors
Guérineau, Nathalie C.
Dumont, Odile
Henrion, Daniel
Loufrani, Laurent
Guihot, Anne-Laure
Abraham, Pierre
Kauffenstein, Gilles
Source
International Journal of Hypertension
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Hypertension is a major risk factor for cardiovascular disorders.
As flow-mediated outward remodeling has a key role in postischemic revascularization, we investigated this remodeling in mesenteric resistance arteries of normotensive (WKY) and spontaneously hypertensive rats (SHRs) aged 3 to 9 months.
Sequential ligation of mesenteric resistance arteries allowed modifying blood flow in vivo, thus exposing arteries to low, normal, or high flow.
After 1, 3, 8, or 24 weeks, arteries were isolated for in vitro study.
High flow (HF) induced outward hypertrophic remodeling in WKY rats after 1 week and persisted until 24 weeks without change in wall to lumen ratio.
In SHRs, diameter increase was delayed, occurring only after 3 weeks.
Nevertheless, it was reduced at 8 weeks and no longer significant after 24 weeks.
In parallel, media cross-section area increased more with time in SHRs than in WKY rats and this was associated with increased contractility and oxidative stress with decreased NO-dependent relaxation.
Low flow induced progressive inward remodeling until 24 weeks in both strains with excessive hypertrophy in SHRs.
Thus, a chronic increase in flow induced transitory diameter expansion and long-lasting hypertrophy in SHRs.
This could contribute to the higher susceptibility of hypertensive subjects to ischemic diseases.
American Psychological Association (APA)
Dumont, Odile& Kauffenstein, Gilles& Guihot, Anne-Laure& Guérineau, Nathalie C.& Abraham, Pierre& Loufrani, Laurent…[et al.]. 2014. Time-Related Alteration in Flow- (Shear Stress-) Mediated Remodeling in Resistance Arteries from Spontaneously Hypertensive Rats. International Journal of Hypertension،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-504036
Modern Language Association (MLA)
Dumont, Odile…[et al.]. Time-Related Alteration in Flow- (Shear Stress-) Mediated Remodeling in Resistance Arteries from Spontaneously Hypertensive Rats. International Journal of Hypertension No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-504036
American Medical Association (AMA)
Dumont, Odile& Kauffenstein, Gilles& Guihot, Anne-Laure& Guérineau, Nathalie C.& Abraham, Pierre& Loufrani, Laurent…[et al.]. Time-Related Alteration in Flow- (Shear Stress-) Mediated Remodeling in Resistance Arteries from Spontaneously Hypertensive Rats. International Journal of Hypertension. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-504036
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504036