Ex Vivo Evaluation of Insulin Nanoparticles Using Chitosan and Arabic Gum
Joint Authors
Mohamadpour Dounighi, Naser
Dinarvand, Rassoul
Avadi, M. R.
Sadeghi, A. M. M.
Rafiee-Tehrani, Morteza
Atyabi, Fatemeh
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
Polymeric delivery systems based on nanoparticles have emerged as a promising approach for peroral insulin delivery.
The aim of the present study was to investigate the release of insulin nanoparticulate systems and ex vivo studies.
The nanoparticles were prepared by the ion gelation method.
Particle size distribution, zeta potential, and polydispersity index of the nanoparticles were determined.
It was found that the nanoparticles carried positive charges and showed a size distribution in the range of 170–200 nm.
The electrostatic interactions between the positively charged group of chitosan and negatively charged groups of Arabic gum play an important role in the association efficiency of insulin in nanoparticles.
In vitro insulin release studies showed an initial burst followed by a slow release of insulin.
The mucoadhesion of the nanosystem was evaluated using excised rat jejunum.
Ex vivo studies have shown a significant increase in absorption of insulin in the presence of chitosan nanoparticles in comparison with free insulin.
American Psychological Association (APA)
Avadi, M. R.& Sadeghi, A. M. M.& Mohamadpour Dounighi, Naser& Dinarvand, Rassoul& Atyabi, Fatemeh& Rafiee-Tehrani, Morteza. 2011. Ex Vivo Evaluation of Insulin Nanoparticles Using Chitosan and Arabic Gum. ISRN Pharmaceutics،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-504047
Modern Language Association (MLA)
Avadi, M. R.…[et al.]. Ex Vivo Evaluation of Insulin Nanoparticles Using Chitosan and Arabic Gum. ISRN Pharmaceutics No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-504047
American Medical Association (AMA)
Avadi, M. R.& Sadeghi, A. M. M.& Mohamadpour Dounighi, Naser& Dinarvand, Rassoul& Atyabi, Fatemeh& Rafiee-Tehrani, Morteza. Ex Vivo Evaluation of Insulin Nanoparticles Using Chitosan and Arabic Gum. ISRN Pharmaceutics. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-504047
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504047