LC and UV Methods for Lamotrigine Determination in Pharmaceutical Formulation

Joint Authors

Steppe, Martin
Martins, Magda T.
Paim, Clésio S.

Source

Chromatography Research International

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-02-17

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Chemistry

Abstract EN

Liquid chromatography (LC) and ultraviolet spectrophotometric (UV) methods for lamotrigine (LTG) determination were validated.

The LC separation was achieved on an ACE RP-18 as stationary phase and 0.3% triethylamine in water (v/v) pH 4.0 : methanol (62 : 38, v/v) as mobile phase.

Detection was achieved with a photodiode array at 279 nm.

The detection response for LTG was linear (r2=0.9999).

The specificity and stability were proved using stress conditions.

The CV (%) values for intraday and interday precision were less than 2.0%.

The method was accurate and robust.

The t-student test proved that the LC and UV methods are interchangeable.

American Psychological Association (APA)

Martins, Magda T.& Paim, Clésio S.& Steppe, Martin. 2011. LC and UV Methods for Lamotrigine Determination in Pharmaceutical Formulation. Chromatography Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-504053

Modern Language Association (MLA)

Martins, Magda T.…[et al.]. LC and UV Methods for Lamotrigine Determination in Pharmaceutical Formulation. Chromatography Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-504053

American Medical Association (AMA)

Martins, Magda T.& Paim, Clésio S.& Steppe, Martin. LC and UV Methods for Lamotrigine Determination in Pharmaceutical Formulation. Chromatography Research International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-504053

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-504053