LC and UV Methods for Lamotrigine Determination in Pharmaceutical Formulation
Joint Authors
Steppe, Martin
Martins, Magda T.
Paim, Clésio S.
Source
Chromatography Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Liquid chromatography (LC) and ultraviolet spectrophotometric (UV) methods for lamotrigine (LTG) determination were validated.
The LC separation was achieved on an ACE RP-18 as stationary phase and 0.3% triethylamine in water (v/v) pH 4.0 : methanol (62 : 38, v/v) as mobile phase.
Detection was achieved with a photodiode array at 279 nm.
The detection response for LTG was linear (r2=0.9999).
The specificity and stability were proved using stress conditions.
The CV (%) values for intraday and interday precision were less than 2.0%.
The method was accurate and robust.
The t-student test proved that the LC and UV methods are interchangeable.
American Psychological Association (APA)
Martins, Magda T.& Paim, Clésio S.& Steppe, Martin. 2011. LC and UV Methods for Lamotrigine Determination in Pharmaceutical Formulation. Chromatography Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-504053
Modern Language Association (MLA)
Martins, Magda T.…[et al.]. LC and UV Methods for Lamotrigine Determination in Pharmaceutical Formulation. Chromatography Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-504053
American Medical Association (AMA)
Martins, Magda T.& Paim, Clésio S.& Steppe, Martin. LC and UV Methods for Lamotrigine Determination in Pharmaceutical Formulation. Chromatography Research International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-504053
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504053