![](/images/graphics-bg.png)
Coronary Artery Disease : A Study on the Joint Role of Birth Weight, Adenosine Deaminase, and Gender
Joint Authors
Paradisi, Giancarlo
Magrini, A.
Lucarini, N.
Ianniello, F.
Saccucci, Patrizia
Gloria-Bottini, F.
Bottini, E.
Banci, Maria
Source
Cardiology Research and Practice
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
An inverse relationship between birth weight and coronary artery diseases is well documented but it remains unclear which exposure in early life might underlie such association.
Recently it has been reported an association between adenosine deaminase genetic polymorphism and coronary artery diseases.
Gender differences in the degree of this association have been also observed.
These observations prompted us to study the possible joint effects of BW, ADA, and gender on the susceptibility to coronary artery diseases.
222 subjects admitted to hospital for nonfatal coronary artery diseases, and 762 healthy consecutive newborns were studied.
ADA genotypes were determined by DNA analysis.
A highly significant complex relationship has emerged among ADA, birth weight, and gender concerning their role on susceptibility to coronary artery diseases in adult life.
Odds ratio analysis suggests that low birth weight is more important in females than in males.
ADA∗2 allele appears protective in males, while in females such effect is obscured by birth weight.
American Psychological Association (APA)
Gloria-Bottini, F.& Banci, Maria& Saccucci, Patrizia& Lucarini, N.& Ianniello, F.& Paradisi, Giancarlo…[et al.]. 2010. Coronary Artery Disease : A Study on the Joint Role of Birth Weight, Adenosine Deaminase, and Gender. Cardiology Research and Practice،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-504071
Modern Language Association (MLA)
Gloria-Bottini, F.…[et al.]. Coronary Artery Disease : A Study on the Joint Role of Birth Weight, Adenosine Deaminase, and Gender. Cardiology Research and Practice No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-504071
American Medical Association (AMA)
Gloria-Bottini, F.& Banci, Maria& Saccucci, Patrizia& Lucarini, N.& Ianniello, F.& Paradisi, Giancarlo…[et al.]. Coronary Artery Disease : A Study on the Joint Role of Birth Weight, Adenosine Deaminase, and Gender. Cardiology Research and Practice. 2010. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-504071
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504071