Preparation and Characterization of Self-Emulsified Docetaxel
Joint Authors
Kim, Da Yeon
Kang, Yun Mi
Kim, Jae Ho
Kang, Kkot Nim
Lee, Ju Young
Kim, Moon Suk
Kim, Gyeong Hae
Kim, E. Sle
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Engineering Sciences and Information Technology
Chemistry
Civil Engineering
Abstract EN
The aim of this paper was to prepare a self-microemulsifying docetaxel (Dtx) using PLGA, Tetraglycol, Labrasol, and Cremophor ELP.
The prepared Dtx-loaded self-microemulsifying system (SMES) showed the initial size of the range of 80–100 nm with narrow size distribution and the negative zeta-potential values.
Its morphology was a spherical shape by atomic force microscopy.
In experiment of stability, Dtx-loaded SMES prepared in DW and BSA condition showed good stability at 37∘C for 7 days.
The viability of the B16F10 cells incubated with Dtx-loaded SMES, Dtx-solution, and Taxol were decreased as a function of incubation time.
In conclusion, we confirmed that Dtx-loaded SMES showed an inhibitory effect for proliferation of B16F10 melanoma cells.
American Psychological Association (APA)
Kim, Gyeong Hae& Lee, Ju Young& Kang, Yun Mi& Kang, Kkot Nim& Kim, E. Sle& Kim, Da Yeon…[et al.]. 2010. Preparation and Characterization of Self-Emulsified Docetaxel. Journal of Nanomaterials،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-504074
Modern Language Association (MLA)
Kim, Gyeong Hae…[et al.]. Preparation and Characterization of Self-Emulsified Docetaxel. Journal of Nanomaterials No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-504074
American Medical Association (AMA)
Kim, Gyeong Hae& Lee, Ju Young& Kang, Yun Mi& Kang, Kkot Nim& Kim, E. Sle& Kim, Da Yeon…[et al.]. Preparation and Characterization of Self-Emulsified Docetaxel. Journal of Nanomaterials. 2010. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-504074
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504074
