Cytotoxicity Effects of Amoora rohituka and chittagonga on Breast and Pancreatic Cancer Cells
Joint Authors
Chan, Leo L.
Ahmad, Irfan
Cunningham, Brian T.
Watkin, Kenneth L.
George, Sherine
Gosangari, Saujanya L.
Abbasi, Atiya
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Chemotherapeutic agents for cancer are highly toxic to healthy tissues and hence alternative medicine avenues are widely researched.
Majority of the recent studies on alternative medicine suggested that Amoora rohituka possesses considerable antitumor and antibacterial properties.
In this work, rohituka and chittagonga, fractionated with petroleum ether, dichloromethane, and ethanol, were explored for their anticancer potential against two breast cancer (MCF-7 and HTB-126) and three pancreatic cancer (Panc-1, Mia-Paca2, and Capan1).
The human foreskin fibroblast, Hs68, was also included.
Cytotoxicity of each extract was analyzed using the MTT assay and label-free photonic crystal biosensor assay.
A concentration series of each extract was performed on the six cell lines.
For MCF-7 cancer cells, the chittagonga (Pet-Ether and CH2Cl2) and rohituka (Pet-Ether) extracts induced cytotoxicity; the chittagonga (EtoAC) and rohituka (MeOH) extracts did not induce cytotoxicity.
For HTB126, Panc-1, Mia-Paca2, and Capan-1 cancer cells, only the chittagonga CH2Cl2 extract showed a significant cytotoxic effect.
The extracts were not cytotoxic to normal fibroblast Hs68 cells, which may be correlated to the specificity of Amoora extracts in targeting cancerous cells.
Based on these results, further examination of the potential anticancer properties Amoora species and the identification of the active ingredients of these extracts is warranted.
American Psychological Association (APA)
Chan, Leo L.& George, Sherine& Ahmad, Irfan& Gosangari, Saujanya L.& Abbasi, Atiya& Cunningham, Brian T.…[et al.]. 2011. Cytotoxicity Effects of Amoora rohituka and chittagonga on Breast and Pancreatic Cancer Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-504106
Modern Language Association (MLA)
Chan, Leo L.…[et al.]. Cytotoxicity Effects of Amoora rohituka and chittagonga on Breast and Pancreatic Cancer Cells. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-504106
American Medical Association (AMA)
Chan, Leo L.& George, Sherine& Ahmad, Irfan& Gosangari, Saujanya L.& Abbasi, Atiya& Cunningham, Brian T.…[et al.]. Cytotoxicity Effects of Amoora rohituka and chittagonga on Breast and Pancreatic Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-504106
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504106