Diffusion Tensor Imaging Studies on Chinese Patients with Social Anxiety Disorder
Joint Authors
Feng, Yuan
Qiu, Changjian
Huang, Xiao Qi
Meng, Yajing
Wu, Ruizhi
Gong, Qi Yong
Nie, Xiaojing
Zhu, Chunyan
Zhang, Wei
Zhang, Jing-na
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of this study was to explore white-matter disruption in social anxiety disorder (SAD) patients by using diffusion tensor imaging (DTI) and to investigate the relationship between cerebral abnormalities and the severity of the symptoms.
Eighteen SAD patients and age- and gender-matched healthy controls were recruited.
DTI scans were performed to measure fractional anisotropy (FA) and apparent diffusion coefficient (ADC) for each subject.
We used voxel-based analysis to determine the differences of FA and ADC values between the two groups with two-sample t-tests.
The SAD patient showed significantly decreased FA values in the white matter of the left insula, left inferior frontal gyrus, left middle temporal gyrus, and left inferior parietal gyrus and increased ADC values in the left insula, bilateral inferior frontal gyrus, bilateral middle temporal gyrus, and left inferior parietal gyrus.
In SAD patients, we observed a significant negative correlation between FA values in the left insula and the total LSAS scores and a positive correlation between the ADC values in the left inferior frontal gyrus and the total LSAS scores.
Above results suggested that white-matter microstructural changes might contribute to the neuropathology of SAD.
American Psychological Association (APA)
Qiu, Changjian& Zhu, Chunyan& Zhang, Jing-na& Nie, Xiaojing& Feng, Yuan& Meng, Yajing…[et al.]. 2014. Diffusion Tensor Imaging Studies on Chinese Patients with Social Anxiety Disorder. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-504112
Modern Language Association (MLA)
Qiu, Changjian…[et al.]. Diffusion Tensor Imaging Studies on Chinese Patients with Social Anxiety Disorder. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-504112
American Medical Association (AMA)
Qiu, Changjian& Zhu, Chunyan& Zhang, Jing-na& Nie, Xiaojing& Feng, Yuan& Meng, Yajing…[et al.]. Diffusion Tensor Imaging Studies on Chinese Patients with Social Anxiety Disorder. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-504112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504112