Reproducibility of Retinal Nerve Fiber Layer Measurements with Manual and Automated Centration in Healthy Subjects Using Spectralis Spectral-Domain Optical Coherence Tomography
Joint Authors
Traboulsee, Anthony L.
Sadjadi, Reza
Lange, Alex P.
Guber, Ivo
Costello, Fiona
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
The aim of this study was to test the reproducibility of the Heidelberg Spectralis SD-OCT and to determine if provided software retest function for follow-up exam is superior to manual centration.
Design.
Prospective, cross-sectional study.
Participants.
20 healthy subjects.
Methods.
All subjects underwent SD-OCT testing to determine retinal nerve fiber layer (RNFL) measurements sequentially on two different days and with two different centration techniques.
Within-subject standard deviation, coefficient of variation, and intraclass correlation coefficient were used to assess reproducibility.
Results.
RNFL measurements showed high reproducibility, low within-subject standard deviation (1.3), low coefficient of variation (0.63%), and low intra-class correlation coefficient (0.98 (95% CI 0.97–0.99)) in the automated centration and manual centration groups for average RNFL Thickness.
Quadrants showed slightly higher variability in the manual group compared to the automated group (within-subject standard deviation 2.5–5.3 versus 1.1–2.4, resp.).
Conclusions.
SD-OCT provides high-resolution RNFL measurements with high reproducibility and low variability.
The re-test function allows for easier recentration for longitudinal examinations with similar results in average RNFL, but less variability in quadrant RNFL.
SD-OCT high reproducibility and low variability is a promising fact and should be further evaluated in longitudinal studies of RNFL.
American Psychological Association (APA)
Lange, Alex P.& Sadjadi, Reza& Costello, Fiona& Guber, Ivo& Traboulsee, Anthony L.. 2012. Reproducibility of Retinal Nerve Fiber Layer Measurements with Manual and Automated Centration in Healthy Subjects Using Spectralis Spectral-Domain Optical Coherence Tomography. ISRN Ophthalmology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-504128
Modern Language Association (MLA)
Lange, Alex P.…[et al.]. Reproducibility of Retinal Nerve Fiber Layer Measurements with Manual and Automated Centration in Healthy Subjects Using Spectralis Spectral-Domain Optical Coherence Tomography. ISRN Ophthalmology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-504128
American Medical Association (AMA)
Lange, Alex P.& Sadjadi, Reza& Costello, Fiona& Guber, Ivo& Traboulsee, Anthony L.. Reproducibility of Retinal Nerve Fiber Layer Measurements with Manual and Automated Centration in Healthy Subjects Using Spectralis Spectral-Domain Optical Coherence Tomography. ISRN Ophthalmology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-504128
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504128