The Triggering Receptor Expressed on Myeloid Cells 2 : “TREM-ming” the Inflammatory Component Associated with Alzheimer's Disease
Author
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by a progressive loss of memory and cognitive skills.
Although much attention has been devoted concerning the contribution of the microscopic lesions, senile plaques, and neurofibrillary tangles to the disease process, inflammation has long been suspected to play a major role in the etiology of AD.
Recently, a novel variant in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) has been identified that has refocused the spotlight back onto inflammation as a major contributing factor in AD.
Variants in TREM2 triple one's risk of developing late-onset AD.
TREM2 is expressed on microglial cells, the resident macrophages in the CNS, and functions to stimulate phagocytosis on one hand and to suppress cytokine production and inflammation on the other hand.
The purpose of this paper is to discuss these recent developments including the potential role that TREM2 normally plays and how loss of function may contribute to AD pathogenesis by enhancing oxidative stress and inflammation within the CNS.
In this context, an overview of the pathways linking beta-amyloid, neurofibrillary tangles (NFTs), oxidative stress, and inflammation will be discussed.
American Psychological Association (APA)
Rohn, Troy T.. 2013. The Triggering Receptor Expressed on Myeloid Cells 2 : “TREM-ming” the Inflammatory Component Associated with Alzheimer's Disease. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-504138
Modern Language Association (MLA)
Rohn, Troy T.. The Triggering Receptor Expressed on Myeloid Cells 2 : “TREM-ming” the Inflammatory Component Associated with Alzheimer's Disease. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-504138
American Medical Association (AMA)
Rohn, Troy T.. The Triggering Receptor Expressed on Myeloid Cells 2 : “TREM-ming” the Inflammatory Component Associated with Alzheimer's Disease. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-504138
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504138