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Sequence Characterization of the MC1R Gene in Yak (Poephagus grunniens) Breeds with Different Coat Colors
Joint Authors
Chen, Shi-Yi
Fontanesi, Luca
Huang, Yi
Liu, Yi-Ping
Yao, Yong-Gang
Zhu, Qing
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-06-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Melanocortin 1 receptor (MC1R) gene plays a key role in determining coat color in several species, including the cattle.
However, up to now there is no report regarding the MC1R gene and the potential association of its mutations with coat colors in yak (Poephagus grunniens).
In this study, we sequenced the encoding region of the MC1R gene in three yak breeds with completely white (Tianzhu breed) or black coat color (Jiulong and Maiwa breeds).
The predicted coding region of the yak MC1R gene resulted of 954 bp, the same to that of the wild-type cattle sequence, with >99% identity.
None of the mutation events reported in cattle was found.
Comparing the yak obtained sequences, five nucleotide substitutions were detected, which defined three haplotypes (EY1, EY2, and EY3).
Of the five mutations, two, characterizing the EY1 haplotype, were nonsynonymous substitutions (c.340C>A and c.871G>A) causing amino acid changes located in the first extracellular loop (p.Q114K) and in the seventh transmembrane region (p.A291T).
In silico prediction might indicate a functional effect of the latter substitution.
However, all three haplotypes were present in the three yak breeds with relatively consistent frequency distribution, despite of their distinguished coat colors, which suggested that there was no across-breed association between haplotypes or genotypes and black/white phenotypes, at least in the investigated breeds.
Other genes may be involved in affecting coat color in the analyzed yaks.
American Psychological Association (APA)
Chen, Shi-Yi& Huang, Yi& Zhu, Qing& Fontanesi, Luca& Yao, Yong-Gang& Liu, Yi-Ping. 2009. Sequence Characterization of the MC1R Gene in Yak (Poephagus grunniens) Breeds with Different Coat Colors. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-504145
Modern Language Association (MLA)
Zhu, Qing…[et al.]. Sequence Characterization of the MC1R Gene in Yak (Poephagus grunniens) Breeds with Different Coat Colors. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-504145
American Medical Association (AMA)
Chen, Shi-Yi& Huang, Yi& Zhu, Qing& Fontanesi, Luca& Yao, Yong-Gang& Liu, Yi-Ping. Sequence Characterization of the MC1R Gene in Yak (Poephagus grunniens) Breeds with Different Coat Colors. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-504145
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504145