![](/images/graphics-bg.png)
Virtual Screening as a Technique for PPAR Modulator Discovery
Joint Authors
Bassaganya-Riera, Josep
Lewis, Stephanie N.
Bevan, David R.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-09-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Virtual screening (VS) is a discovery technique to identify novel compounds with therapeutic and preventive efficacy against disease.
Our current focus is on the in silico screening and discovery of novel peroxisome proliferator-activated receptor-gamma (PPARγ) agonists.
It is well recognized that PPARγ agonists have therapeutic applications as insulin sensitizers in type 2 diabetes or as anti-inflammatories.
VS is a cost- and time-effective means for identifying small molecules that have therapeutic potential.
Our long-term goal is to devise computational approaches for testing the PPARγ-binding activity of extensive naturally occurring compound libraries prior to testing agonist activity using ligand-binding and reporter assays.
This review summarizes the high potential for obtaining further fundamental understanding of PPARγ biology and development of novel therapies for treating chronic inflammatory diseases through evolution and implementation of computational screening processes for immunotherapeutics in conjunction with experimental methods for calibration and validation of results.
American Psychological Association (APA)
Lewis, Stephanie N.& Bassaganya-Riera, Josep& Bevan, David R.. 2009. Virtual Screening as a Technique for PPAR Modulator Discovery. PPAR Research،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-504156
Modern Language Association (MLA)
Lewis, Stephanie N.…[et al.]. Virtual Screening as a Technique for PPAR Modulator Discovery. PPAR Research No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-504156
American Medical Association (AMA)
Lewis, Stephanie N.& Bassaganya-Riera, Josep& Bevan, David R.. Virtual Screening as a Technique for PPAR Modulator Discovery. PPAR Research. 2009. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-504156
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504156