Mycophenolic Acid Overcomes Imatinib and Nilotinib Resistance of Chronic Myeloid Leukemia Cells by Apoptosis or a Senescent-Like Cell Cycle Arrest
Joint Authors
Gioia, Romain
Drullion, Claire
Cardinaud, Bruno
Pasquet, Jean-Max
Mahon, François-Xavier
Lippert, Eric
Legembre, Patrick
Lagarde, Valérie
Priault, Muriel
Source
Leukemia Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Mechanical Engineering
Medicine
Abstract EN
We used K562 cells sensitive or generated resistant to imatinib or nilotinib to investigate their response to mycophenolic acid (MPA).
MPA induced DNA damage leading to cell death with a minor contribution of apoptosis, as revealed by annexin V labeling (up to 25%).
In contrast, cell cycle arrest and positive staining for senescence-associated β-galactosidase activity were detected for a large cell population (80%).
MPA-induced cell death was potentialized by the inhibition of autophagy and this is associated to the upregulation of apoptosis.
In contrast, senescence was neither decreased nor abrogated in autophagy deficient K562 cells.
Primary CD34 cells from CML patients sensitive or resistant to imatinib or nilotinib respond to MPA although apoptosis is mainly detected.
These results show that MPA is an interesting tool to overcome resistance in vitro and in vivo mainly in the evolved phase of the disease.
American Psychological Association (APA)
Drullion, Claire& Lagarde, Valérie& Gioia, Romain& Legembre, Patrick& Priault, Muriel& Cardinaud, Bruno…[et al.]. 2012. Mycophenolic Acid Overcomes Imatinib and Nilotinib Resistance of Chronic Myeloid Leukemia Cells by Apoptosis or a Senescent-Like Cell Cycle Arrest. Leukemia Research and Treatment،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-504164
Modern Language Association (MLA)
Drullion, Claire…[et al.]. Mycophenolic Acid Overcomes Imatinib and Nilotinib Resistance of Chronic Myeloid Leukemia Cells by Apoptosis or a Senescent-Like Cell Cycle Arrest. Leukemia Research and Treatment No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-504164
American Medical Association (AMA)
Drullion, Claire& Lagarde, Valérie& Gioia, Romain& Legembre, Patrick& Priault, Muriel& Cardinaud, Bruno…[et al.]. Mycophenolic Acid Overcomes Imatinib and Nilotinib Resistance of Chronic Myeloid Leukemia Cells by Apoptosis or a Senescent-Like Cell Cycle Arrest. Leukemia Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-504164
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504164