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Cytomorphology of Circulating Colorectal Tumor Cells : A Small Case Series
Joint Authors
Bethel, Kelly
Clark, Peter
Lazar, Daniel
Fisher, Jennifer
Nieva, Jorge
Marrinucci, Dena
Kuhn, Peter
Bruce, Richard
Huynh, Edward
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-01-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Several methodologies exist to enumerate circulating tumor cells (CTCs) from the blood of cancer patients; however, most methodologies lack high-resolution imaging, and thus, little is known about the cytomorphologic features of these cells.
In this study of metastatic colorectal cancer patients, we used immunofluorescent staining with fiber-optic array scanning technology to identify CTCs, with subsequent Wright-Giemsa and Papanicolau staining.
The CTCs were compared to the corresponding primary and metastatic tumors.
The colorectal CTCs showed marked intrapatient pleomorphism.
In comparison to the corresponding tissue biopsies, cells from all sites showed similar pleomorphism, demonstrating that colorectal CTCs retain the pleomorphism present in regions of solid growth.
They also often retain particular cytomorphologic features present in the patient's primary and/or metastatic tumor tissue.
This study provides an initial analysis of the cytomorphologic features of circulating colon cancer cells, providing a foundation for further investigation into the significance and metastatic potential of CTCs.
American Psychological Association (APA)
Marrinucci, Dena& Bethel, Kelly& Lazar, Daniel& Fisher, Jennifer& Huynh, Edward& Clark, Peter…[et al.]. 2010. Cytomorphology of Circulating Colorectal Tumor Cells : A Small Case Series. Journal of Oncology،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-504168
Modern Language Association (MLA)
Marrinucci, Dena…[et al.]. Cytomorphology of Circulating Colorectal Tumor Cells : A Small Case Series. Journal of Oncology No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-504168
American Medical Association (AMA)
Marrinucci, Dena& Bethel, Kelly& Lazar, Daniel& Fisher, Jennifer& Huynh, Edward& Clark, Peter…[et al.]. Cytomorphology of Circulating Colorectal Tumor Cells : A Small Case Series. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-504168
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504168