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Perceptions and Referral Trends into Phase I Oncology Trials : Results of a Clinical Survey
Joint Authors
de Bono, Johann
Barriuso, Jorge
Arkenau, Hendrik-Tobias
Yap, Timomy
Olmos, David
Kaye, Stan
Tan, Daniel
Brunetto, Andre
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
A survey was sent to referring oncologists (ROs) to explore the reasons behind their referral patterns and perceptions of Phase I studies before and after being provided with outcome data from advanced colorectal cancer (ACRC) patients who participated in Phase I trials at the Royal Marsden Hospital (RMH).
Results.
The response rate was 32/50 (64%).
The most common reason for referral was exhaustion of standard treatments (31%), and the main reason for referring to the RMH was proximity to patients (28%).
The most frequent clinical parameter assessed prior to referral was performance status (93%).
ROs spent a median of 15 min (range: 5–45 min) discussing general aspects of Phase I trials.
In the second part of the questionnaire, after reviewing clinical outcome data of ACRC patients who participated in Phase I trials, 47% would change their approach, specifically, spend more time to discuss risks and benefits of Phase I trials (9%), consider prognostic factors before referral (13%), and increase the number of referrals (25%).
Conclusion.
This is the first report focusing on communication between ROs and a specialist Phase I unit.
Outcome reporting can improve communication with ROs and importantly has the potential for better patient selection considered for Phase I oncology trials.
American Psychological Association (APA)
Brunetto, Andre& Olmos, David& Arkenau, Hendrik-Tobias& Tan, Daniel& Yap, Timomy& de Bono, Johann…[et al.]. 2011. Perceptions and Referral Trends into Phase I Oncology Trials : Results of a Clinical Survey. Journal of Oncology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-504175
Modern Language Association (MLA)
Brunetto, Andre…[et al.]. Perceptions and Referral Trends into Phase I Oncology Trials : Results of a Clinical Survey. Journal of Oncology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-504175
American Medical Association (AMA)
Brunetto, Andre& Olmos, David& Arkenau, Hendrik-Tobias& Tan, Daniel& Yap, Timomy& de Bono, Johann…[et al.]. Perceptions and Referral Trends into Phase I Oncology Trials : Results of a Clinical Survey. Journal of Oncology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-504175
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504175