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Nucleotide-Binding Oligomerization Domain-1 and -2 Play No Role in Controlling Brucella abortus Infection in Mice
Joint Authors
Zamboni, Dario S.
Carvalho, Natalia B.
Oliveira, Fernanda S.
Oliveira, Sergio Costa
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Nucleotide-binding oligomerization domain proteins (NODs) are modular cytoplasmic proteins implicated in the recognition of peptidoglycan-derived molecules.
Further, several in vivo studies have demonstrated a role for Nod1 and Nod2 in host defense against bacterial pathogens.
Here, we demonstrated that macrophages from NOD1-, NOD2-, and Rip2-deficient mice produced lower levels of TNF-α following infection with live Brucella abortus compared to wild-type mice.
Similar reduction on cytokine synthesis was not observed for IL-12 and IL-6.
However, NOD1, NOD2, and Rip2 knockout mice were no more susceptible to infection with virulent B.
abortus than wild-type mice.
Additionally, spleen cells from NOD1-, NOD2-, and Rip2-deficient mice showed unaltered production of IFN-γ compared to C57BL/6 mice.
Taken together, this study demonstrates that NOD1, NOD2 and Rip2 are dispensable for the control of B.
abortus during in vivo infection.
American Psychological Association (APA)
Oliveira, Fernanda S.& Carvalho, Natalia B.& Zamboni, Dario S.& Oliveira, Sergio Costa. 2011. Nucleotide-Binding Oligomerization Domain-1 and -2 Play No Role in Controlling Brucella abortus Infection in Mice. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-504177
Modern Language Association (MLA)
Oliveira, Fernanda S.…[et al.]. Nucleotide-Binding Oligomerization Domain-1 and -2 Play No Role in Controlling Brucella abortus Infection in Mice. Clinical and Developmental Immunology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-504177
American Medical Association (AMA)
Oliveira, Fernanda S.& Carvalho, Natalia B.& Zamboni, Dario S.& Oliveira, Sergio Costa. Nucleotide-Binding Oligomerization Domain-1 and -2 Play No Role in Controlling Brucella abortus Infection in Mice. Clinical and Developmental Immunology. 2011. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-504177
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504177